TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
T Song, S Lv, X Ma, X Zhao, L Fan, Q Zou, N Li… - Journal of Biological …, 2023 - ASBMB
Autophagy plays a pivotal role in physiology and pathophysiology, including cancer.
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of …
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of …
[HTML][HTML] Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast …
FL Zhang, SY Yang, L Liao, TM Zhang, YL Zhang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: SUMOylation regulates a plethora of biological processes, and its inhibitors are
currently under investigation in clinical trials as anticancer agents. Thus, identifying new …
currently under investigation in clinical trials as anticancer agents. Thus, identifying new …
Comparative analysis of protein folding stability-based profiling methods for characterization of biological phenotypes
MA Bailey, Y Tang, HJ Park… - Journal of the American …, 2023 - ACS Publications
Recently, a new suite of mass spectrometry-based proteomic methods has been developed
that enables evaluation of protein folding stability on the proteomic scale. These methods …
that enables evaluation of protein folding stability on the proteomic scale. These methods …
ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes
DJ Owen, E Aguilar-Martinez, Z Ji, Y Li, AD Sharrocks - Elife, 2023 - elifesciences.org
ZMYM2 is a zinc finger transcriptional regulator that plays a key role in promoting and
maintaining cell identity. It has been implicated in several diseases such as congenital …
maintaining cell identity. It has been implicated in several diseases such as congenital …