Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Gene ontology analyses of high-confidence autism spectrum disorder (ASD) risk genes
highlight chromatin regulation and synaptic function as major contributors to pathobiology …

Widespread sequencing has yielded thousands of missense variants predicted or confirmed
as disease-causing. This creates a new bottleneck: determining the functional impact of …

Human developmental disorders encompass a wide range of debilitating physical
conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the …

Microtubules (MTs) are dynamic components of the cell cytoskeleton involved in several
cellular functions, such as structural support, migration and intracellular trafficking. Despite …

The protein kinase DYRK1A encoded in human chromosome 21 is the major contributor to
the multiple symptoms observed in Down syndrome patients. In addition, DYRK1A …

The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates
diverse substrates involved in various cellular processes. Here, we found that blocking the …

Background Oxidative stress induced growth inhibitor 1 (OSGIN1) regulates cell death. The
role and underlying molecular mechanism of OSGIN1 in non-small cell lung cancer …

Background Tubulins are highly conserved globular proteins involved in stabilization of
cellular cytoskeletal microtubules during cell cycle. Different isoforms of tubulins are …