[HTML][HTML] Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi
E Bencosme-Cuevas, TK Kim, TT Nguyen… - Frontiers in Cellular …, 2023 - frontiersin.org
Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …
Metabolic modeling predicts unique drug targets in Borrelia burgdorferi
PJ Gwynne, KLK Stocks, ES Karozichian, A Pandit… - Msystems, 2023 - Am Soc Microbiol
ABSTRACT The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent,
with a small genome and correspondingly limited metabolism. As such, it is an excellent …
with a small genome and correspondingly limited metabolism. As such, it is an excellent …
Cholesterol contributes to risk, severity, and machine learning-driven diagnosis of Lyme disease
IS Forrest, AJ O'Neal, JHF Pedra… - Clinical Infectious …, 2023 - academic.oup.com
Background Lyme disease is the most prevalent vector-borne disease in the US, yet its host
factors are poorly understood and diagnostic tests are limited. We evaluated patients in a …
factors are poorly understood and diagnostic tests are limited. We evaluated patients in a …
[HTML][HTML] Cellular and transcriptome signatures unveiled by single-cell RNA-Seq following ex vivo infection of murine splenocytes with Borrelia burgdorferi
V Kumaresan, TMM Ingle, N Kilgore, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Lyme disease, the most common tick-borne infectious disease in the US, is
caused by a spirochetal pathogen Borrelia burgdorferi (Bb). Distinct host responses are …
caused by a spirochetal pathogen Borrelia burgdorferi (Bb). Distinct host responses are …