[HTML][HTML] Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy
N Suzuki, A Nishiyama, H Warita, M Aoki - Journal of human genetics, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …
[HTML][HTML] NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders
Y Zilberter, DR Tabuena, M Zilberter - Progress in Neurobiology, 2023 - Elsevier
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …
[HTML][HTML] Susceptibility and disease modifier genes in amyotrophic lateral sclerosis: from genetic associations to therapeutic implications
SW Willemse, MA van Es - Current Opinion in Neurology, 2023 - journals.lww.com
Technological and methodological advances are enabling researchers to unravel the
genetics of ALS. Both causal mutations and genetic modifiers are viable therapeutic targets …
genetics of ALS. Both causal mutations and genetic modifiers are viable therapeutic targets …
[HTML][HTML] Genomic and transcriptomic advances in amyotrophic lateral sclerosis
M Rizzuti, L Sali, V Melzi, S Scarcella… - Ageing Research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …
[HTML][HTML] Unitigs Are Not Enough: the Advantages of Superunitig-Based Algorithms in Bioinformatics
S Schmidt - 2023 - helda.helsinki.fi
Unitigs are a central construct in many subfields of bioinformatics, including genome
assembly and the compact representation of k-mer spectra. In both of these subfields, using …
assembly and the compact representation of k-mer spectra. In both of these subfields, using …
Genome‐wide meta‐analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population
Y Yu, Q Zhen, W Chen, Y Yu, Z Li… - … Genetics & Genomic …, 2023 - Wiley Online Library
Abstract Background Nonsyndromic orofacial clefts (NSOFCs) are the most common
craniofacial birth malformations in humans and are generally classified as nonsyndromic …
craniofacial birth malformations in humans and are generally classified as nonsyndromic …
Genome-wide Association Clustering Meta-analysis in European and Chinese Datasets for Systemic Lupus Erythematosus identifies new genes
M Saeed - medRxiv, 2023 - medrxiv.org
Genome-wide association studies (GWAS) face multiple challenges in order to identify
reliable susceptibility genes for complex disorders, such as Systemic lupus erythematosus …
reliable susceptibility genes for complex disorders, such as Systemic lupus erythematosus …