Overview on aneuploidy in childhood B-cell acute lymphoblastic leukemia

K Panuciak, E Nowicka, A Mastalerczyk… - International Journal of …, 2023 - mdpi.com
Recent years have brought significant progress in the treatment of B-cell acute
lymphoblastic leukemia (ALL). This was influenced by both the improved schemes of …

Novel strategies to prevent and overcome relapse after allogeneic hematopoietic cell transplantation in acute lymphoblastic leukemia

MH Hodroj, I Abou Dalle, N Moukalled… - Frontiers in …, 2023 - frontiersin.org
The outcome of B-cell acute lymphoblastic leukemia (B-ALL) has improved over time with
the incorporation of multi-agent chemotherapy in the treatment landscape as well as the …

Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia

D Leongamornlert, J Gutiérrez-Abril, SW Lee… - Blood …, 2023 - ashpublications.org
Genomic profiling during the diagnosis of B-cell precursor acute lymphoblastic leukemia
(BCP-ALL) in adults is used to guide disease classification, risk stratification, and treatment …

Real-world use of blinatumomab in adult patients with B-cell acute lymphoblastic leukemia in clinical practice: results from the NEUF study

N Boissel, S Chiaretti, C Papayannidis… - Blood Cancer …, 2023 - nature.com
This retrospective observational study (NEUF) included adult patients with B-cell acute
lymphoblastic leukemia (B-cell ALL) who had received blinatumomab for the treatment of …

Genetic alterations and MRD refine risk assessment for KMT2A-rearranged B-cell precursor ALL in adults: a GRAALL study

R Kim, H Bergugnat, C Pastoret, F Pasquier, E Raffoux… - Blood, 2023 - ashpublications.org
Abstract KMT2A-rearranged (KMT2A-r) B-cell precursor acute lymphoblastic leukemia (BCP-
ALL) is widely recognized as a high-risk leukemia in both children and adults. However …

[HTML][HTML] Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement

S Bomken, A Enshaei, EC Schwalbe… - …, 2023 - ncbi.nlm.nih.gov
Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia
(BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in …

Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B‐lineage acute lymphoblastic …

DG Gupta, N Varma, P Sharma, MI Truica… - Cancer, 2023 - Wiley Online Library
Background The published literature on hematological, clinical, flowcytometric‐
immunophenotyping, and minimal residual disease outcomes of the prognostically important …

Survival outcomes in patients with relapsed/refractory or MRD-positive B-cell acute lymphoblastic leukemia treated with blinatumomab

HM Kantarjian, AC Logan, F Zaman… - Therapeutic …, 2023 - journals.sagepub.com
Blinatumomab has demonstrated significant efficacy in adult and pediatric patients with
relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-cell ALL) and patients with …

Optical genome mapping as a Tool to unveil New Molecular findings in Hematological patients with Complex chromosomal rearrangements

N Coccaro, A Zagaria, L Anelli, F Tarantini, G Tota… - Genes, 2023 - mdpi.com
Standard cytogenetic techniques (chromosomal banding analysis—CBA, and fluorescence
in situ hybridization—FISH) show limits in characterizing complex chromosomal …

New association between splicing factor‐coding gene polymorphisms and the risk of acute lymphoblastic leukemia in southern Chinese children: A five‐center case …

D Deng, A Luo, M Li, Y Yan, M Cai, S Liu… - The Journal of Gene …, 2023 - Wiley Online Library
Background The role of splicing factor‐coding gene polymorphisms in pediatric acute
lymphoblastic leukemia (ALL) susceptibility is still unclear. Methods A case–control …