AIF1: function and connection with inflammatory diseases

D De Leon-Oliva, C Garcia-Montero, O Fraile-Martinez… - Biology, 2023 - mdpi.com
Simple Summary Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein that
participates in intracellular processes such as phagocytosis, membrane ruffling and F-actin …

Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis

NJ Gurule, KC Malcolm, C Harris, JR Knapp… - Leukemia, 2023 - nature.com
Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into
acute myeloid leukemia. Fatal infection is among the most common cause of death in MDS …

Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1

P Chinnasamy, I Casimiro, DF Riascos-Bernal… - Nature …, 2023 - nature.com
Recent studies implicate macrophages in regulation of thermogenic, sympathetic neuron-
mediated norepinephrine (NE) signaling in adipose tissues, but understanding of such non …

Macrophage pathology in hepatotoxicity

J Yamate, T Izawa, M Kuwamura - Journal of Toxicologic Pathology, 2023 - jstage.jst.go.jp
The liver is the most important organ that metabolizes and detoxifies chemicals taken into
the body. Therefore, there is always a risk of liver damage owing to the toxic effects of …

[HTML][HTML] Immune infiltration and immunophenotyping in atrial fibrillation

Y Tian, S Liu, Y Zhang, J Yang, P Guo, H Zhang… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is a relatively common arrhythmia in clinical practice. Although
significant progress has been achieved in the treatment of AF and its associated …

Inhibition of AIF-1 alleviates laser-induced macular neovascularization by inhibiting endothelial cell proliferation via restrained p44/42 MAPK signaling pathway

Q Li, L Hu, G Liu, X Yin, Y Li, X Wei, N Duan… - Experimental Eye …, 2023 - Elsevier
Age-related macular degeneration (AMD) is a leading blinding disease worldwide, and
macular neovascularization (MNV) is a common complication encountered in the advanced …

[HTML][HTML] Combination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant …

A Tada, T Minami, H Kitai, Y Higashiguchi, M Tokuda… - Lung Cancer, 2023 - Elsevier
Malignant pleural mesothelioma (MPM) is an asbestos-related fatal malignant neoplasm.
Although there has been no reliable chemotherapeutic regimen other than combination …