Simple Summary Heat-shock proteins (HSPs) are molecular chaperones overexpressed in
tumor cells and are necessary for their survival. In leukemia and lymphoma, HSPs have …

Charcot–Marie–Tooth disease (CMT) and associated neuropathies are the most
predominant genetically transmitted neuromuscular conditions; however, effective …

Despite great medical advances, oncological research is still looking for novel therapeutic
approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of …

Simple Summary SBI-46, an antiandrogen-equipped histone deacetylase inhibitor, is the
lead compound developed for targeting castration-resistant prostate cancer (CRPC). We …

Androgen and androgen deprivation (castration) therapies, including androgen receptor
antagonists, are clinically used to treat patients with prostate cancer. However, most …

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of
dementia. The pathogenesis is a complex process, in which the proteotoxicity of amyloid-β …

Human histone deacetylase 6 (HDAC6) is a structurally unique, multidomain protein
implicated in a variety of physiological processes including cytoskeletal remodelling and the …

Inhibition of histone deacetylases (HDACs) has proven to be an effective strategy for cancer
therapy. To date, five histone deacetylase inhibitors (HDACis) have been approved for …

Abstract Alzheimer's disease (AD), an advanced multifactorial neurodegenerative disease
mainly accompanied by cognitive impairment, is the most conversant form of dementia …

The heavy metal cadmium (Cd) is one of the major environmental pollution toxicants, which
is highly toxic to the environment and can cause damages to many organs after entering …