Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the
global population. Kidney disease encompasses a diverse group of disorders that vary in …

A major regulator of blood pressure and volume homeostasis in the kidney is the epithelial
sodium channel (ENaC). ENaC is composed of alpha (α)/beta (β)/gamma (γ) or delta …

Nearly 30% of adults consume less than the estimated average daily requirement of
magnesium (Mg2+), and commonly used medications, such as diuretics, promote Mg2+ …

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical
data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein …

The role of psoralen (PS), a major active component extracted from Psoralea corylifolia L.
seed, in renal fibrosis is still unclear. Thus, the objective of this study was to evaluate the …

Salt-sensitivity hypertension (SSHTN) is an independent predictor for cardiovascular
mortality. VEGFC has been reported to be a protective role in SSHTN and hypertensive …

Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone
marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation. This study …

Nod-like receptor protein 3 (NLRP3) is a multi-protein complex belonging to the innate
immune system, whose activation by danger stimuli promotes inflammatory cell death …

Butyrate is a short-chain fatty acid with various pharmacological effects, which was produced
by intestinal flora metabolism, we investigated the role and potential mechanism of sodium …

There has been accumulating interest in the application of medicinal plants as alternative
medicine to treat various diseases and/or to develop modern medicines. Vitex negundo is …