[HTML][HTML] A deep convolutional neural network for efficient microglia detection
I Suleymanova, D Bychkov, J Kopra - Scientific Reports, 2023 - nature.com
Microglial cells are a type of glial cells that make up 10–15% of all brain cells, and they play
a significant role in neurodegenerative disorders and cardiovascular diseases. Despite their …
a significant role in neurodegenerative disorders and cardiovascular diseases. Despite their …
[HTML][HTML] Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
C Falconnier, A Caparros-Roissard, C Decraene… - Molecular …, 2023 - nature.com
In the past two decades, over-prescription of opioids for pain management has driven a
steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll …
steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll …
[HTML][HTML] The effect of morphine on rat microglial phagocytic activity: An in vitro study of brain region-, plating density-, sex-, morphine concentration-, and receptor …
DN King'uyu, L Nti-Kyemereh, JL Bonin… - Journal of …, 2023 - Elsevier
Opioids have long been used for clinical pain management, but also have addictive
properties that have contributed to the ongoing opioid epidemic. While opioid activation of …
properties that have contributed to the ongoing opioid epidemic. While opioid activation of …
Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity
J Wang, Q Ru, X Yu, C Wang, K Li, N Li, J Zhao… - European Journal of …, 2023 - Elsevier
Opioids are widely used in the treatment of moderate and severe pain. Nociceptive
stimulation has been reported to potentially promote microglial activation and …
stimulation has been reported to potentially promote microglial activation and …
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord
FHG Ahlström, H Viisanen, L Karhinen… - Molecular …, 2023 - journals.sagepub.com
Background: Opioids are efficacious and safe analgesic drugs in short-term use for acute
pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial …
pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial …
Intrathecal minocycline does not block the adverse effects of repeated, intravenous morphine administration on recovery of function after SCI
J Rau, L Weise, R Moore, M Terminel, K Brakel… - Experimental …, 2023 - Elsevier
Opioids are among the most effective analgesics for the management of pain in the acute
phase of a spinal cord injury (SCI), and approximately 80% of patients are treated with …
phase of a spinal cord injury (SCI), and approximately 80% of patients are treated with …
Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia
E Ozdemir, O Avcı, ZDS Inan, AS Taskiran… - Metabolic Brain …, 2023 - Springer
Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development
of tolerance to its antinociceptive effect is an important clinical problem. Aspirin is an …
of tolerance to its antinociceptive effect is an important clinical problem. Aspirin is an …
[HTML][HTML] Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain
R Ma, NA Kutchy, Z Wang, G Hu - Molecular Therapy, 2023 - cell.com
Repeated use of opioids such as morphine causes changes in the shape and signal
transduction pathways of various brain cells, including astrocytes and neurons, resulting in …
transduction pathways of various brain cells, including astrocytes and neurons, resulting in …