Droplet-based microfluidic systems generate, manipulate and control sub-microlitre droplets
enclosed within an immiscible carrier fluid. Owing to a number of remarkable features, such …

In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …

Circular consensus sequencing with Pacific Biosciences (PacBio) technology generates
long (10–25 kilobases), accurate 'HiFi'reads by combining serial observations of a DNA …

Stem cell-independent reprogramming of differentiated cells has recently been identified as
an important paradigm for repairing injured tissues. Following periportal injury, mature …

Antibody responses are characterized by increasing affinity and diversity over time. Affinity
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …

US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …

Summary Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …

Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …