Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
Recommendations for the use of metagenomics for routine monitoring of antibiotic resistance in wastewater and impacted aquatic environments
Shotgun metagenomic sequencing of the collective genomic information carried across
microbial communities is emerging as a powerful approach for monitoring antibiotic …
microbial communities is emerging as a powerful approach for monitoring antibiotic …
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
Abstract The Comprehensive Antibiotic Resistance Database (CARD; card. mcmaster. ca)
combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) …
combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) …
[HTML][HTML] Population-level impacts of antibiotic usage on the human gut microbiome
The widespread usage of antimicrobials has driven the evolution of resistance in pathogenic
microbes, both increased prevalence of antimicrobial resistance genes (ARGs) and their …
microbes, both increased prevalence of antimicrobial resistance genes (ARGs) and their …
Deciphering basic and key traits of antibiotic resistome in influent and effluent of hospital wastewater treatment systems
Hospital wastewater treatment system (HWTS) is an important source and environmental
reservoir of clinically relevant antibiotic resistance genes (ARGs). However, how antibiotic …
reservoir of clinically relevant antibiotic resistance genes (ARGs). However, how antibiotic …
Impact of COVID-19 pandemic on profiles of antibiotic-resistant genes and bacteria in hospital wastewater
The COVID-19 pandemic has severely affected healthcare worldwide and has led to the
excessive use of disinfectants and antimicrobial agents. However, the impact of excessive …
excessive use of disinfectants and antimicrobial agents. However, the impact of excessive …
[HTML][HTML] Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group
MJ Tisza, DDN Smith, AE Clark, JH Youn… - Nature …, 2023 - nature.com
Three types of DNA methyl modifications have been detected in bacterial genomes, and
mechanistic studies have demonstrated roles for DNA methylation in physiological functions …
mechanistic studies have demonstrated roles for DNA methylation in physiological functions …
High-risk antibiotics positively correlated with antibiotic resistance genes in five typical urban wastewater
S Sun, Q Wang, N Wang, S Yang, H Qi - Journal of Environmental …, 2023 - Elsevier
Antibiotic resistance genes (ARGs) and antibiotic amount increased within close proximity to
human dominated ecosystems. However, few studies assessed the distribution of antibiotics …
human dominated ecosystems. However, few studies assessed the distribution of antibiotics …
[HTML][HTML] Resolving colistin resistance and heteroresistance in Enterobacter species
Species within the Enterobacter cloacae complex (ECC) include globally important
nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter …
nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter …
A proposed framework for the identification of indicator genes for monitoring antibiotic resistance in wastewater: Insights from metagenomic sequencing
Antibiotic resistance is one of the greatest threats to global human and animal health of our
time. Municipal wastewater has been identified as a hotspot of antibiotic resistance …
time. Municipal wastewater has been identified as a hotspot of antibiotic resistance …