The spleen is a gatekeeper of systemic immunity where immune responses against blood-
borne pathogens are initiated and sustained. Non-haematopoietic stromal cells construct …

Formation of long-lasting memory lymphocytes is one of the foundational characteristics of
adaptive immunity and the basis of many vaccination strategies. Following the rapid …

Abstract NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor
cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic …

The increasing use of nuclear energy sources inevitably raises the risk of accidental or
deliberate radiation exposure and associated immune dysfunction. However, the extent to …

The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses
in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but …

Increased demand for novel, highly effective vaccination strategies necessitates a better
understanding of long-lived memory CD8 T cell differentiation. To achieve this …

CD8+ effector cells are highly skilled in immune surveillance and contribute to adaptive
immunity against cancer cells. An increasing number of molecular factors affecting T-cell …

CD8 T cells with regenerative capacity are required to sustain successful cytotoxic T-
lymphocytes (CTL) mediated immune responses to acute (T Stem) and chronic (T Prog) …

The past decade has seen a rapid progress in identifying the complex tumor-immune
interactions that occur in the tumor micro-environment (TME), on the basis of which …

MDSCs are suppressive immune cells with a high relevance in various pathologies
including cancer, autoimmunity, and chronic infections. Surface marker expression of …