Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia

M Hagan, G Pankov, R Gallegos-Monterrosa… - Nature …, 2023 - nature.com
Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial
effector proteins into neighbouring bacterial cells, representing an important mechanism of …

Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality

RP Singh, K Kumari - Biotechnology letters, 2023 - Springer
Bacterial secretion systems are nanomolecular complexes that release a diverse set of
virulence factors/or proteins into its surrounding or translocate to their target host cells …

Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease

A Kayongo, NM Robertson, T Siddharthan… - Frontiers in …, 2023 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global
mortality, with three million deaths reported annually. This impact is expected to increase …

Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria

S Robitaille, EL Simmons, AJ Verster… - Nature ecology & …, 2023 - nature.com
Understanding the relationship between the composition of the human gut microbiota and
the ecological forces shaping it is of great importance; however, knowledge of the …

Interplay of broccoli/broccoli sprout bioactives with gut microbiota in reducing inflammation in inflammatory bowel diseases

J Holman, M Hurd, PL Moses, GM Mawe… - The Journal of nutritional …, 2023 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD) are chronic, reoccurring, and debilitating
conditions characterized by inflammation in the gastrointestinal tract, some of which can …

Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales

DE Bosch, R Abbasian, B Parajuli, SB Peterson… - Mbio, 2023 - Am Soc Microbiol
Bacteroidales use type VI secretion systems (T6SS) to competitively colonize and persist in
the colon. We identify a horizontally transferred T6SS with Ntox15 family nuclease effector …

Bacteria-driven bio-therapy: from fundamental studies to clinical trials

Y Yu, S Lin, Z Chen, B Qin, Z He, M Cheng, M Sun… - Nano Today, 2023 - Elsevier
Natural bacteria have been utilized to directly maintain the human body's homeostasis for
directly or indirectly relieving diseases throughout history. With the rapid development of …

The Role of Biogeography in Shaping Intestinal Flora and Influence on Fatty Acid Composition in Red Swamp Crayfish (Procambarus clarkii)

M Chen, S Su, C Zhang, J Zhu, W Feng, H Chen… - Microbial Ecology, 2023 - Springer
Intestinal microbiota plays an important role in promoting digestion, metabolism, and
immunity. Intestinal microbiota and fatty acids are important indicators to evaluate the health …