The pharmacokinetic–pharmacodynamic modelling framework as a tool to predict drug resistance evolution
Pharmacokinetic–pharmacodynamic (PKPD) models, which describe how drug
concentrations change over time and how that affects pathogen growth, have proven highly …
concentrations change over time and how that affects pathogen growth, have proven highly …
Revisiting the in-vitro and in-vivo considerations for in-silico modelling of complex injectable drug products
Complex injectable drug products (CIDPs) have often been developed to modulate the
pharmacokinetics along with efficacy for therapeutic agents used for remediation of chronic …
pharmacokinetics along with efficacy for therapeutic agents used for remediation of chronic …
C-Reactive protein as an early predictor of efficacy in advanced non-small-cell lung cancer patients: a tumor dynamics-biomarker modeling framework
Simple Summary In oncology, the identification of early predictors of response/survival is of
particular interest. C-reactive protein (CRP) concentrations have been associated with …
particular interest. C-reactive protein (CRP) concentrations have been associated with …
Hierarchical Bayesian pharmacometrics analysis of Baclofen for alcohol use disorder
Alcohol use disorder (AUD), also called alcohol dependence, is a major public health
problem, affecting almost $10\% $ of the world's population. Baclofen, as a selective …
problem, affecting almost $10\% $ of the world's population. Baclofen, as a selective …
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin
In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we
explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models …
explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models …
Population pharmacokinetics and pharmacodynamics of carfilzomib in combination with rituximab, ifosfamide, carboplatin, and etoposide in adult patients with …
LH Lin, M Ghasemi, SM Burke, CK Mavis, JR Nichols… - Targeted Oncology, 2023 - Springer
Background In patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma
(DLBCL), salvage chemotherapy regimens (eg, rituximab, ifosfamide, carboplatin, and …
(DLBCL), salvage chemotherapy regimens (eg, rituximab, ifosfamide, carboplatin, and …
Mind the Gap: Model-Based Switching from Selatogrel to Maintenance Therapy with Oral P2Y12 Receptor Antagonists
Background: The P2Y12 receptor antagonist selatogrel is being developed for
subcutaneous self-administration with a ready-to-use autoinjector at the onset of acute …
subcutaneous self-administration with a ready-to-use autoinjector at the onset of acute …
Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model
The prognosis for pancreatic ductal adenocarcinoma (PDAC) patients has not significantly
improved in the past 3 decades, highlighting the need for more effective treatment …
improved in the past 3 decades, highlighting the need for more effective treatment …
Methotrexate Polyglutamates Exposure–Response Modeling in a Large Cohort of Rheumatoid Arthritis Patients Starting Methotrexate
RCF Hebing, IH Bartelink, HR Gosselt… - Clinical …, 2023 - Wiley Online Library
Methotrexate polyglutamates (MTX‐PG) concentrations in red blood cells (RBCs) have been
suggested as a biomarker of response in patients with rheumatoid arthritis (RA) receiving …
suggested as a biomarker of response in patients with rheumatoid arthritis (RA) receiving …
Robust and adaptive two-stage designs in nonlinear mixed effect models
L Fayette, R Leroux, F Mentré, J Seurat - The AAPS Journal, 2023 - Springer
To get informative studies for nonlinear mixed effect models (NLMEM), design optimization
can be performed based on Fisher Information Matrix (FIM) using the D-criterion. Its …
can be performed based on Fisher Information Matrix (FIM) using the D-criterion. Its …