The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological …

P Ferdinandy, I Andreadou, GF Baxter, HE Bøtker… - Pharmacological …, 2023 - ASPET
Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Mitochondrial connexins and mitochondrial contact sites with gap junction structure

S Cetin-Ferra, SC Francis, AT Cooper… - International Journal of …, 2023 - mdpi.com
Mitochondria contain connexins, a family of proteins that is known to form gap junction
channels. Connexins are synthesized in the endoplasmic reticulum and oligomerized in the …

Differential intracellular management of fatty acids impacts on metabolic stress-stimulated glucose uptake in cardiomyocytes

E Vanni, K Lindner, AC Gavin, C Montessuit - Scientific Reports, 2023 - nature.com
Stimulation of glucose uptake in response to ischemic metabolic stress is important for
cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) …

Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing

Y Li, FM Acosta, JX Jiang - Biomolecules, 2023 - mdpi.com
Fibrosis initially appears as a normal response to damage, where activated fibroblasts
produce large amounts of the extracellular matrix (ECM) during the wound healing process …

Thymoquinone reduces methotrexate-induced heart damage: a histopathological study in rats

AB Yıldırım, E Kaymak, T Ceylan, A Akın… - Cukurova Medical …, 2023 - dergipark.org.tr
Purpose: The study aimed to evaluate the effect of thymoquinone on cardiac tissue in MTX-
induced cardiac toxicity in rats with various parameters. Materials and Methods: Group I (n …