[HTML][HTML] The link between mitochondrial dysfunction and sarcopenia: an update focusing on the role of pyruvate dehydrogenase kinase 4

MJ Kim, IS Sinam, Z Siddique… - … & Metabolism Journal, 2023 - synapse.koreamed.org
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by
mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not …

Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity

C Billon, S Sitaula, S Banerjee, R Welch… - ACS Chemical …, 2023 - ACS Publications
Repetitive physical exercise induces physiological adaptations in skeletal muscle that
improves exercise performance and is effective for the prevention and treatment of several …

ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency

H Xia, C Scholtes, CR Dufour, C Guluzian… - Molecular Metabolism, 2023 - Elsevier
Objective Estrogen related receptor α (ERRα) occupies a central node in the transcriptional
control of energy metabolism, including in skeletal muscle, but whether modulation of its …

[HTML][HTML] Innately expressed estrogen-related receptors in the skeletal muscle are indispensable for exercise fitness

DH Sopariwala, AS Rios, G Pei, A Roy… - … : official publication of …, 2023 - ncbi.nlm.nih.gov
Transcriptional determinants in the skeletal muscle that govern exercise capacity, while
poorly defined, could provide molecular insights into how exercise improves fitness. Here …

Association of Macronutrients Intake with Body Composition and Sarcopenic Obesity in Children and Adolescents: A Population-Based Analysis of the National Health …

B Yang, C Tang, Z Shi, L Gao - Nutrients, 2023 - mdpi.com
The association of macronutrients intake with body composition and sarcopenic obesity
remains uncertain in children and adolescents. We aimed to explore the association …

Acute exercise in a hot environment increases heat shock protein 70 and peroxisome proliferator-activated receptor γ coactivator 1α mRNA in Thoroughbred horse …

Y Ebisuda, K Mukai, Y Takahashi, T Yoshida… - Frontiers in Veterinary …, 2023 - frontiersin.org
Heat acclimatization or acclimation training in horses is practiced to reduce physiological
strain and improve exercise performance in the heat, which can involve metabolic …

MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer

J Ding, Y Wen, X Yuan, X He - Genome Instability & Disease, 2023 - Springer
Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to
support energy-intensive and biosynthetic requirements for exuberant proliferation and …

Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915

CS Hampton, S Sitaula, C Billon, K Haynes… - European Journal of …, 2023 - Elsevier
Estrogen-related receptors (ERR) are an orphan nuclear receptor sub-family that play a
critical role in regulating gene transcription for several physiological processes including …

Adriamycin downregulates the expression of KLF4 in cardiomyocytes in vitro and contributes to impaired cardiac energy metabolism in Adriamycin-induced …

UP Mohan, PBT Pichiah, S Arunachalam - 3 Biotech, 2023 - Springer
Adriamycin is a well-known anthracycline chemotherapeutic agent widely used in treating a
variety of malignancies. However, Adriamycin's clinical use is limited due to its adverse side …

CcpA-Knockout Staphylococcus aureus Induces Abnormal Metabolic Phenotype via the Activation of Hepatic STAT5/PDK4 Signaling in Diabetic Mice

Y Li, J Cai, Y Liu, C Li, X Chen, WL Wong, W Jiang… - Pathogens, 2023 - mdpi.com
Catabolite control protein A (CcpA), an important global regulatory protein, is extensively
found in S. aureus. Many studies have reported that CcpA plays a pivotal role in regulating …