Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
Calcins are peptides from scorpion venom with the unique ability to cross cell membranes,
gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion …
gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion …
Downregulation of FKBP5 promotes atrial arrhythmogenesis
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
PI3K (p110α) as a determinant and gene therapy for atrial enlargement in atrial fibrillation
M Ezeani, S Prabhu - Molecular and Cellular Biochemistry, 2023 - Springer
Atrial fibrillation (AF) is an irregular heart rhythm, characterised by chaotic atrial activation,
which is promoted by remodelling. Once initiated, AF can also propagate the progression of …
which is promoted by remodelling. Once initiated, AF can also propagate the progression of …
Targeting ryanodine receptors to treat human diseases
AR Marks - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
This Review provides an update on ryanodine receptors (RyRs) and their role in human
diseases of heart, muscle, and brain. Calcium (Ca2+) is a requisite second messenger in all …
diseases of heart, muscle, and brain. Calcium (Ca2+) is a requisite second messenger in all …
[HTML][HTML] Qi-Po-Sheng-Mai granule ameliorates Ach-CaCl2-induced atrial fibrillation by regulating calcium homeostasis in cardiomyocytes
S Shi, X Mao, J Lv, Y Wang, X Zhang, X Shou, B Zhang… - Phytomedicine, 2023 - Elsevier
Background Atrial fibrillation (AF) is one of the most common arrhythmias encountered in
clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits …
clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits …
Chronic catestatin treatment reduces atrial fibrillation susceptibility via improving calcium handling in post-infarction heart failure rats
M Yan, T Liu, P Zhong, F Xiong, B Cui, J Wu, G Wu - Peptides, 2023 - Elsevier
Abstract Background Abnormal Ca 2+ handling is a pivotal element of atrial fibrillation (AF)
substrates. Catestatin (CST) modulates intracellular Ca 2+ handling in cardiomyocytes …
substrates. Catestatin (CST) modulates intracellular Ca 2+ handling in cardiomyocytes …
Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial …
Aims Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial
remodelling manifesting as acute and chronic alterations in expression, function, and …
remodelling manifesting as acute and chronic alterations in expression, function, and …
Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death
Y Qian, D Zuo, J Xiong, Y Yin, R Qi, X Ma, A Yan… - Europace, 2023 - academic.oup.com
Abstract Aims The ryanodine receptor 2 (RyR2) is essential for cardiac muscle excitation–
contraction coupling; dysfunctional RyR2 participates in the development of inherited …
contraction coupling; dysfunctional RyR2 participates in the development of inherited …
Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease
A Deb, BD Tow, Y Qing, M Walker, ER Hodges… - Cells, 2023 - mdpi.com
The brief opening mode of the mitochondrial permeability transition pore (mPTP) serves as a
calcium (Ca2+) release valve to prevent mitochondrial Ca2+ (mCa2+) overload …
calcium (Ca2+) release valve to prevent mitochondrial Ca2+ (mCa2+) overload …
Kinase Inhibitors and Atrial Fibrillation: Mechanisms of Action and Clinical Implications
Recent advances have significantly expanded the options of available therapeutics for
cancer treatment, including novel targeted cancer therapies. Within this broad category of …
cancer treatment, including novel targeted cancer therapies. Within this broad category of …