New perspectives on sex differences in learning and memory
AW Fleischer, KM Frick - Trends in Endocrinology & Metabolism, 2023 - cell.com
Females have historically been disregarded in memory research, including the thousands of
studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in …
studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in …
Defective proteostasis in Alzheimer's disease
The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for
brain processes, including learning and memory. Increasing evidence indicates that …
brain processes, including learning and memory. Increasing evidence indicates that …
The ubiquitin-proteasome system and learning-dependent synaptic plasticity–A 10 year update
Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala
Females are more likely than males to develop post-traumatic stress disorder (PTSD).
However, the neurobiological mechanisms responsible for these sex differences remain …
However, the neurobiological mechanisms responsible for these sex differences remain …
[HTML][HTML] Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
K Farrell, A Auerbach, C Liu, K Martin, M Pareno… - Biology of sex …, 2023 - Springer
Background Sex differences have been observed in several brain regions for the molecular
mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin …
mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin …
Neuronal and astrocytic protein degradation are critical for fear memory formation
Strong evidence has implicated proteasome-mediated protein degradation in the memory
consolidation process. However, due to the use of pharmacological approaches, the cell …
consolidation process. However, due to the use of pharmacological approaches, the cell …
Sex difference in the facilitation of fear learning by prior fear conditioning
KE Cole, RG Parsons - Neurobiology of Learning and Memory, 2023 - Elsevier
There is now ample evidence that the strength and underlying mechanisms of memory
formation can be drastically altered by prior experience. However, the prior work using …
formation can be drastically altered by prior experience. However, the prior work using …
Hypothalamic DNA 5-hydroxymethylation levels are altered by diet-induced weight gain during the development of obesity in a sex-specific manner
Obesity is a major health concern that is associated with altered gene transcription in the
hypothalamus. However, the mechanisms controlling this gene expression dysregulation …
hypothalamus. However, the mechanisms controlling this gene expression dysregulation …
[HTML][HTML] Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity
T McFadden, N Gaito, I Carucci, E Fletchall, K Farrell… - Plos one, 2023 - journals.plos.org
Obesity is a complex medical condition that is linked to various health complications such as
infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for …
infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for …
Fear response of rat pups to a non‐aversive social stimulus: Evidence for the involvement of memory processes
MJ Zuluaga, D Agrati, V Athaíde… - Developmental …, 2023 - Wiley Online Library
Learning processes in rats during early development are importantly mediated by the
mother, which represents the primary source of environmental information. This study aimed …
mother, which represents the primary source of environmental information. This study aimed …