Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …
Emerging strategies for the treatment of small cell lung cancer: a review
WJ Petty, L Paz-Ares - JAMA oncology, 2023 - jamanetwork.com
Importance Small cell lung cancer (SCLC) is an aggressive disease that is characterized by
rapid growth and the early development of metastases. Patients typically respond to initial …
rapid growth and the early development of metastases. Patients typically respond to initial …
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
Current knowledge of small cell lung cancer transformation from non-small cell lung cancer
G Giaccone, Y He - Seminars in Cancer Biology, 2023 - Elsevier
Lung cancer is the leading cause of cancer related death, and is divided into two major
histological subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer …
histological subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer …
Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histologic transformation
Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …
Genomic ALK alterations in primary and relapsed neuroblastoma
C Rosswog, J Fassunke, A Ernst… - British Journal of …, 2023 - nature.com
Background Genomic alterations of the anaplastic lymphoma kinase gene (ALK) occur
recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system …
recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system …
Dynamics of sequence and structural cell-free DNA landscapes in small-cell lung cancer
Purpose: Patients with small-cell lung cancer (SCLC) have an exceptionally poor prognosis,
calling for improved real-time noninvasive biomarkers of therapeutic response. Experimental …
calling for improved real-time noninvasive biomarkers of therapeutic response. Experimental …
FGFR families: biological functions and therapeutic interventions in tumors
Q Liu, J Huang, W Yan, Z Liu, S Liu, W Fang - MedComm, 2023 - Wiley Online Library
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
Advancing breast cancer heterogeneity analysis: Insights from genomics, transcriptomics and proteomics at bulk and single-cell levels
Z Zhu, L Jiang, X Ding - Cancers, 2023 - mdpi.com
Simple Summary This review discusses the heterogeneity of breast cancer and strategies to
understand it using multi-omics profiling methods at the traditional bulk and single-cell …
understand it using multi-omics profiling methods at the traditional bulk and single-cell …