[HTML][HTML] Comorbidities of atopic dermatitis—what does the evidence say?
JP Thyssen, AS Halling, P Schmid-Grendelmeier… - Journal of Allergy and …, 2023 - Elsevier
Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic
comorbidities. There has been a growing interest in this area of AD, because presence or …
comorbidities. There has been a growing interest in this area of AD, because presence or …
Interleukin-4 as a therapeutic target
Abstract Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global …
Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with
allergic rhinitis and food allergy and cause high morbidity and mortality both in children and …
allergic rhinitis and food allergy and cause high morbidity and mortality both in children and …
Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials
A Blauvelt, JP Thyssen… - British Journal of …, 2023 - academic.oup.com
Background Lebrikizumab is a novel, high-affinity monoclonal antibody that selectively binds
to interleukin (IL)-13. Objectives To evaluate the efficacy and safety of lebrikizumab …
to interleukin (IL)-13. Objectives To evaluate the efficacy and safety of lebrikizumab …
Spatial transcriptomics combined with single‐cell RNA‐sequencing unravels the complex inflammatory cell network in atopic dermatitis
Y Mitamura, M Reiger, J Kim, Y Xiao, D Zhakparov… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …
Dupilumab has a profound effect on specific‐IgE levels of several food allergens in atopic dermatitis patients.
LS Spekhorst, LP van der Rijst, M de Graaf… - Allergy, 2023 - search.ebscohost.com
Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic
dermatitis patients Error bars indicate the 95% confidence interval. gl This is the first study …
dermatitis patients Error bars indicate the 95% confidence interval. gl This is the first study …
Spesolimab, an anti‐interleukin‐36 receptor antibody, in patients with moderate‐to‐severe atopic dermatitis: Results from a multicentre, randomized, double‐blind …
R Bissonnette, W Abramovits… - Journal of the …, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease, and
there is increasing evidence that the interleukin (IL)‐36 pathway may play a role in the …
there is increasing evidence that the interleukin (IL)‐36 pathway may play a role in the …
[HTML][HTML] Microbial dysbiosis tunes the immune response towards allergic disease outcomes
The hygiene hypothesis has been popularized as an explanation for the rapid increase in
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …
Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood
L Maintz, MT Schmitz, N Herrmann, S Müller… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease.
However, there is growing evidence for a high rate of adult‐onset AD. We aimed to …
However, there is growing evidence for a high rate of adult‐onset AD. We aimed to …
[HTML][HTML] Lebrikizumab for the treatment of moderate-to-severe atopic dermatitis
D Bernardo, T Bieber, T Torres - American Journal of Clinical Dermatology, 2023 - Springer
Atopic dermatitis (AD) is a common, heterogeneous, inflammatory skin disorder
characterized by chronic or relapsing eczematous lesions with intense pruritus and …
characterized by chronic or relapsing eczematous lesions with intense pruritus and …