[HTML][HTML] Comorbidities of atopic dermatitis—what does the evidence say?

JP Thyssen, AS Halling, P Schmid-Grendelmeier… - Journal of Allergy and …, 2023 - Elsevier
Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic
comorbidities. There has been a growing interest in this area of AD, because presence or …

Interleukin-4 as a therapeutic target

Y Gärtner, L Bitar, F Zipp, CF Vogelaar - Pharmacology & Therapeutics, 2023 - Elsevier
Abstract Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …

Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global …

YH Shin, J Hwang, R Kwon, SW Lee, MS Kim… - Allergy, 2023 - Wiley Online Library
Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with
allergic rhinitis and food allergy and cause high morbidity and mortality both in children and …

Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials

A Blauvelt, JP Thyssen… - British Journal of …, 2023 - academic.oup.com
Background Lebrikizumab is a novel, high-affinity monoclonal antibody that selectively binds
to interleukin (IL)-13. Objectives To evaluate the efficacy and safety of lebrikizumab …

Spatial transcriptomics combined with single‐cell RNA‐sequencing unravels the complex inflammatory cell network in atopic dermatitis

Y Mitamura, M Reiger, J Kim, Y Xiao, D Zhakparov… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …

Dupilumab has a profound effect on specific‐IgE levels of several food allergens in atopic dermatitis patients.

LS Spekhorst, LP van der Rijst, M de Graaf… - Allergy, 2023 - search.ebscohost.com
Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic
dermatitis patients Error bars indicate the 95% confidence interval. gl This is the first study …

Spesolimab, an anti‐interleukin‐36 receptor antibody, in patients with moderate‐to‐severe atopic dermatitis: Results from a multicentre, randomized, double‐blind …

R Bissonnette, W Abramovits… - Journal of the …, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease, and
there is increasing evidence that the interleukin (IL)‐36 pathway may play a role in the …

[HTML][HTML] Microbial dysbiosis tunes the immune response towards allergic disease outcomes

T Augustine, M Kumar, S Al Khodor… - Clinical Reviews in …, 2023 - Springer
The hygiene hypothesis has been popularized as an explanation for the rapid increase in
allergic disease observed over the past 50 years. Subsequent epidemiological studies have …

Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood

L Maintz, MT Schmitz, N Herrmann, S Müller… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease.
However, there is growing evidence for a high rate of adult‐onset AD. We aimed to …

[HTML][HTML] Lebrikizumab for the treatment of moderate-to-severe atopic dermatitis

D Bernardo, T Bieber, T Torres - American Journal of Clinical Dermatology, 2023 - Springer
Atopic dermatitis (AD) is a common, heterogeneous, inflammatory skin disorder
characterized by chronic or relapsing eczematous lesions with intense pruritus and …