[HTML][HTML] microRNAs as Biomarkers of Endothelial Dysfunction and Therapeutic Target in the Pathogenesis of Atrial Fibrillation
V Desantis, MA Potenza, L Sgarra, C Nacci… - International Journal of …, 2023 - mdpi.com
The pathophysiology of atrial fibrillation (AF) may involve atrial fibrosis/remodeling and
dysfunctional endothelial activities. Despite the currently available treatment approaches …
dysfunctional endothelial activities. Despite the currently available treatment approaches …
[HTML][HTML] Atrial Fibrillation and Diabetes Mellitus: Dangerous Liaisons or Innocent Bystanders?
A Lorenzo-Almoros, J Casado Cerrada… - Journal of Clinical …, 2023 - mdpi.com
Atrial fibrillation (AF) is the most common arrhythmia in adults and diabetes mellitus (DM) is
a major risk factor for cardiovascular diseases. However, the relationship between both …
a major risk factor for cardiovascular diseases. However, the relationship between both …
The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency
K Kim, DJ Blackwell, SL Yuen, MP Thorpe… - Journal of molecular and …, 2023 - Elsevier
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of
stroke and morbidity. The strongest genetic risk factors for AF in humans are variants on …
stroke and morbidity. The strongest genetic risk factors for AF in humans are variants on …
[HTML][HTML] Mitochondrial dysfunction in cardiac arrhythmias
Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to
mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying …
mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying …
[HTML][HTML] Inhibition of the voltage-gated potassium channel Kv1. 5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling
MM Al-Owais, NT Hettiarachchi, ML Dallas… - Communications …, 2023 - nature.com
The voltage-gated K+ channel plays a key role in atrial excitability, conducting the ultra-rapid
rectifier K+ current (IKur) and contributing to the repolarization of the atrial action potential. In …
rectifier K+ current (IKur) and contributing to the repolarization of the atrial action potential. In …
Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes
Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase
in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF) …
in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF) …
[HTML][HTML] Electro-mechanical alterations in atrial fibrillation: Structural, electrical, and functional correlates
I Pozios, AI Vouliotis, P Dilaveris, C Tsioufis - Journal of Cardiovascular …, 2023 - mdpi.com
Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting
both patients' survival and well-being. Apart from aging, many cardiovascular risk factors …
both patients' survival and well-being. Apart from aging, many cardiovascular risk factors …
Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases
S Chen, S Guan, Z Yan, F Ouyang… - International …, 2023 - spandidos-publications.com
Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny
and the maintenance of homeostasis. In the last decade, it has been demonstrated that the …
and the maintenance of homeostasis. In the last decade, it has been demonstrated that the …
[HTML][HTML] Pitx2c deficiency confers cellular electrophysiological hallmarks of atrial fibrillation to isolated atrial myocytes
Aims Atrial fibrillation (AF) has been associated with altered expression of the transcription
factor Pitx2c and a high incidence of calcium release-induced afterdepolarizations …
factor Pitx2c and a high incidence of calcium release-induced afterdepolarizations …
Atrial fibrillation is an independent risk factor for new-onset myocardial infarction: a prospective study
J Wu, Q Hou, Q Han, R Mao, B Yue, J Yu… - Acta …, 2023 - Taylor & Francis
Background Atrial fibrillation (AF) and myocardial infarction (MI) share common
cardiovascular risk factors, therefore coexistence of AF and MI is very common, in addition …
cardiovascular risk factors, therefore coexistence of AF and MI is very common, in addition …