Personalizing adjuvant therapy for patients with colorectal cancer

L Yang, J Yang, A Kleppe, HE Danielsen… - Nature Reviews Clinical …, 2024 - nature.com
The current standard-of-care adjuvant treatment for patients with colorectal cancer (CRC)
comprises a fluoropyrimidine (5-fluorouracil or capecitabine) as a single agent or in …

[HTML][HTML] Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

S Pant, ZA Wainberg, CD Weekes, M Furqan… - Nature medicine, 2024 - nature.com
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor
DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P …

Applications of liquid biopsy for surgical patients with cancer: a review

KM Mahuron, Y Fong - JAMA surgery, 2024 - jamanetwork.com
Importance Liquid biopsy is an emerging tool with the potential to change oncologic care
practices. Optimal clinical applications for its use are currently undefined for surgical …

Comparing the Diagnostic Performance of Quantitative PCR, Digital Droplet PCR, and Next-Generation Sequencing Liquid Biopsies for Human Papillomavirus …

S Naegele, DA Ruiz-Torres, Y Zhao, D Goss… - The Journal of Molecular …, 2024 - Elsevier
Human papillomavirus (HPV)-associated cancers, including oropharyngeal squamous cell
carcinoma (HPV+ OPSCC), cervical cancer, and squamous cell carcinoma of the anus …

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

AJ Widman, M Shah, A Frydendahl, D Halmos… - Nature Medicine, 2024 - nature.com
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through
accurate assessment of minimal residual disease (MRD) and therapeutic response …

[HTML][HTML] Unraveling the potential clinical utility of circulating tumor DNA detection in colorectal cancer—evaluation in a nationwide Danish cohort

TV Henriksen, C Demuth, A Frydendahl, J Nors… - Annals of …, 2024 - Elsevier
Background Increasingly, circulating tumor DNA (ctDNA) is proposed as a tool for minimal
residual disease (MRD) assessment. Digital PCR (dPCR) offers low analysis costs and …

[HTML][HTML] Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: A multicenter prospective observational study

T Saito, Y Kurokawa, K Fujitani, R Kawabata… - British Journal of …, 2024 - nature.com
Background No reliable marker has been identified to predict postoperative recurrence of
gastric cancer. We designed a clinical trial to investigate the utility of serum NY-ESO-1 …

[HTML][HTML] Role of circulating tumor DNA among patients with colorectal peritoneal metastases

JM Baumgartner, GP Botta - Journal of Gastrointestinal Cancer, 2024 - Springer
Purpose This was a review of circulating tumor DNA (ctDNA) in patients with peritoneal
metastases from colorectal cancer. Methods We searched the PubMed database for studies …

[HTML][HTML] Error-corrected deep targeted sequencing of circulating cell-free DNA from colorectal cancer patients for sensitive detection of circulating tumor DNA

A Frydendahl, MH Rasmussen, SØ Jensen… - International Journal of …, 2024 - mdpi.com
Circulating tumor DNA (ctDNA) is a promising biomarker, reflecting the presence of tumor
cells. Sequencing-based detection of ctDNA at low tumor fractions is challenging due to the …

A practical approach to interpreting circulating tumor DNA in the management of gastrointestinal cancers

Z Allan, DS Liu, MM Lee, J Tie, NJ Clemons - Clinical Chemistry, 2024 - academic.oup.com
Background There is accumulating evidence supporting the clinical use of circulating tumor
DNA (ctDNA) in solid tumors, especially in different types of gastrointestinal cancer. As such …