An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations
Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main
protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in …
protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in …
Recent advances in the design of small molecular drugs with acrylamides covalent warheads
L Liang, Z Zhang, Q You, X Guo - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
In the development of covalent inhibitors, acrylamides warhead is one of the most popular
classes of covalent warheads. In recent years, researchers have made different structural …
classes of covalent warheads. In recent years, researchers have made different structural …
[HTML][HTML] Hepatitis C Elimination in Egypt: Story of Success
Egypt has long been overwhelmed by the hepatitis C virus (HCV) infection, and it used to be
the country with the world's highest prevalence rates. The disease had been a significant …
the country with the world's highest prevalence rates. The disease had been a significant …
[HTML][HTML] The deleterious effects of sofosbuvir and ribavirin (antiviral drugs against hepatitis C virus) on different body systems in male albino rats regarding …
Sofosbuvir is one of the crucial drugs used in the treatment of chronic hepatitis C virus (HCV)
in adults and children with compensated liver disease, including cirrhosis. It may be used …
in adults and children with compensated liver disease, including cirrhosis. It may be used …
A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease
Flavivirus infection usually results in fever accompanied by headache, arthralgia, and, in
some cases, rash. Although the symptoms are mild, full recovery can take several months …
some cases, rash. Although the symptoms are mild, full recovery can take several months …
[HTML][HTML] Unveiling potent inhibitors for schistosomiasis through ligand-based drug design, molecular docking, molecular dynamics simulations and pharmacokinetics …
Schistosomiasis is a neglected tropical disease which imposes a considerable and enduring
impact on affected regions, leading to persistent morbidity, hindering child development …
impact on affected regions, leading to persistent morbidity, hindering child development …
Rationale for Hepatitis C Virus Treatment During Hematopoietic Stem Cell Transplant in the Era of Novel Direct-Acting Antivirals
Z Makovich, I Radosavljevic, S Chapyala… - Digestive Diseases and …, 2024 - Springer
Methods A literature review was performed to summarize the available data on the impact of
HCV on patients undergoing HSCT. Drug-drug interactions for DAA's and pertinent HSCT …
HCV on patients undergoing HSCT. Drug-drug interactions for DAA's and pertinent HSCT …
[HTML][HTML] The Impact of the G6PD Gene Mutations in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Multicenter Observational Study
C Smirne, MG Crobu, C Gerevini, AM Berton, R Rapetti… - Genes, 2024 - mdpi.com
Following the advent of direct-acting antivirals (DAAs), the treatment of hepatitis C virus
(HCV) infection is now rarely challenging. However, data are still limited concerning DAA …
(HCV) infection is now rarely challenging. However, data are still limited concerning DAA …
Безинтерфероновая терапия хронического гепатита С: смена препаратов или новая парадигма лечения?
CН Бацких - Российский журнал гастроэнтерологии, гепатологии …, 2024 - gastro-j.ru
Безинтерфероновая терапия хронического гепатита С: смена препаратов Page 1 23
Гепатология 4, 2014 РЖГГК он-лайн – www.gastro-j.ru Безинтерфероновая терапия …
Гепатология 4, 2014 РЖГГК он-лайн – www.gastro-j.ru Безинтерфероновая терапия …
[PDF][PDF] Maha Abd‑El Baki Ahmed 5, Mohammed H. Hassan 6, Emaad Abdel‑Kahaar 7, 8 & Rehab H. Abdel‑Aziz 9
Scientific Reports|(2024) 14: 5682| https://doi. org/10.1038/s41598-024-55950-5 www.
nature. com/scientificreports/triglyceride, and lipase, which exhibit a significant increase …
nature. com/scientificreports/triglyceride, and lipase, which exhibit a significant increase …