G Protein-Coupled Receptors: A Century of Research and Discovery
S Liu, PJ Anderson, S Rajagopal, RJ Lefkowitz… - Circulation …, 2024 - Am Heart Assoc
GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors,
are the largest receptor family in the human genome, with≈ 800 members. GPCRs regulate …
are the largest receptor family in the human genome, with≈ 800 members. GPCRs regulate …
How new developments in pharmacology receptor theory are changing (our understanding of) hypertension therapy
SW Watts, RR Townsend… - American Journal of …, 2024 - academic.oup.com
Background Many hypertension therapeutics were developed prior to major advances in
drug receptor theory. Moreover, newer drugs may take advantage of some of the newly …
drug receptor theory. Moreover, newer drugs may take advantage of some of the newly …
[HTML][HTML] G protein–coupled receptors: from radioligand binding to cellular signaling
HA Rockman, RJ Lefkowitz - The Journal of Clinical …, 2024 - Am Soc Clin Investig
JCI - G protein–coupled receptors: from radioligand binding to cellular signaling Go to JCI
Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by …
Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by …
The β-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with KA Values Distinct From Their Equilibrium …
The determination of affinity by using functional assays is important in drug discovery
because it provides a more relevant estimate of the strength of interaction of a ligand to its …
because it provides a more relevant estimate of the strength of interaction of a ligand to its …
Beta-2 adrenoreceptor modulators and methods of using same
AD Mackerell, D Deshpande, C Lind… - US Patent App. 18 …, 2024 - Google Patents
NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2, 4-diaminoquinazolin-6-yl) ethyl]
benzoyl] amino]-4-methylidenepentanedioic acid Chemical compound C1= CC2= NC (N) …
benzoyl] amino]-4-methylidenepentanedioic acid Chemical compound C1= CC2= NC (N) …