[HTML][HTML] Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism

S Jekhmane, MGN Derks, S Maity, CJ Slingerland… - Nature …, 2024 - nature.com
Antimicrobial resistance is a leading cause of mortality, calling for the development of new
antibiotics. The fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks …

Medium-sized peptides from microbial sources with potential for antibacterial drug development

J Chen, W Wang, X Hu, Y Yue, X Lu, C Wang… - Natural Product …, 2024 - pubs.rsc.org
Covering: 1993 to the end of 2022As the rapid development of antibiotic resistance shrinks
the number of clinically available antibiotics, there is an urgent need for novel options to fill …

[HTML][HTML] Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier

S Wang, Y Yang, X Jiang, X Zheng, Q Wei, W Dai… - Cell Death …, 2024 - nature.com
The intestinal lumen acts as a critical interface connecting the external environment with the
body's internal state. It's essential to prevent the passage of harmful antigens and bacteria …

PM2. 5 Causes Increased Bacterial Invasion by Affecting HBD1 Expression in the Lung

T Zheng, Y Wang, Z Zhou, S Chen… - Journal of …, 2024 - Wiley Online Library
Our research addresses the critical environmental issue of a fine particulate matter (PM2. 5),
focusing on its association with the increased infection risks. We explored the influence of …

Single Deletion Unmasks Hidden Anti-Gram-Negative Bacterial Activity of an Insect Defensin-Derived Peptide

B Gao, P Li, S Zhu - Journal of Medicinal Chemistry, 2024 - ACS Publications
Insect defensins are a large family of antimicrobial peptides primarily active against Gram-
positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …

Design of a Novel Lysine Isopeptide 1018KI11 with Potent Antimicrobial Activity as a Safe and Stable Food Preservative Candidate

Q Wang, Y Yang, X Dong, H Wang… - Journal of Agricultural …, 2024 - ACS Publications
Antimicrobial peptides are potent food additive candidates, but most of them are sensitive to
proteases, which limits their application. Therefore, we substituted arginine for lysine and …

[HTML][HTML] Expression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus

K Zhang, N Yang, D Teng, R Mao, Y Hao… - Applied Microbiology and …, 2024 - Springer
The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The
improvement of activity and yield through modification and heterologous expression, a …

Defensins: A novel weapon against Mycobacterium tuberculosis?

X Gao, J Feng, L Wei, P Dong, J Chen, L Zhang… - International …, 2024 - Elsevier
Tuberculosis (TB) is a serious airborne communicable disease caused by organisms of the
Mycobacterium tuberculosis (Mtb) complex. Although the standard treatment antimicrobials …

[HTML][HTML] Identification of Genes Associated with Resistance to Persulcatusin, a Tick Defensin from Ixodes persulcatus

S Shimoda, J Ito, T Ando, R Tobe, K Nakagawa… - Microorganisms, 2024 - mdpi.com
Antimicrobial peptides (AMPs) are present in a wide range of plants, animals, and
microorganisms. Since AMPs are characterized by their effectiveness against emergent …

Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin

NBM Janzing, CHR Senges, P Dietze, B Haltli… - …, 2024 - Wiley Online Library
Pseudopteroxazole (Ptx) and the pseudopterosins are marine natural products with
promising antibacterial potential. While Ptx has attracted interest for its antimycobacterial …