Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …

Alzheimer's Disease (AD) is a disorder characterized by cognitive decline,
neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in …

As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal
socioeconomic challenge to the aging population and is largely attributed to intervertebral …

Background and objective: Epithelial ovarian cancer (EOC) is associated with latent onset
and poor prognosis, with drug resistance being a main concern in improving the prognosis …

Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

The association of genomic loci to the nuclear periphery is proposed to facilitate cell type-
specific gene repression and influence cell fate decisions. However, the interplay between …

Cellular senescence occurs in response to endogenous or exogenous stresses and is
characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of …

Ethnopharmacological relevance Sepsis-induced lung injury is closely associated with it
remarkable morbidity and mortality. Shenhuangdan (SHD) decoction, a traditional Chinese …

Aging is a major risk factor for many diseases. Recent studies have shown that age-related
disruption of proteostasis leads to the accumulation of abnormal proteins and that …