Quinazoline compounds have gained significant attention in the fields of agriculture and
chemistry due to their diverse activities. In this study, we focused on a series of quinazoline …

Epidemiological studies predict that chicken eggs contain constituents other than proteins
that prevent Alzheimer's disease. This study screened for constituents that inhibit the …

A simplified synthetic method yielded diverse 2-aminobenzothiazole variants through
sulfonylation and amino group alkylation. Extensive characterization via X-ray diffraction …

Eight new hybrid constructs containing a series of sulfonamide and 1, 2, 3-triazole units
were designed and synthesized. Anticancer, antioxidant and cholinesterase activities of …

Abstract Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are useful markers
to assess the effects of exposure to anticholinesterase insecticides (Anti-AChE). In addition …

Cholinesterases (ChEs) are pivotal in the pathophysiology of various neuromuscular
diseases, including Parkinson's disease, Alzheimer's disease, myasthenia gravis, and …

Discovery of therapeutics for multifactorial diseases and disorders involving multiple
pathophysiological pathways is still a challenge for the researchers. Alzheimer's disease …

Cholinesterase (ChE) inhibitors are under consideration to be used in the treatment of
cardiovascular pathologies. A prerequisite to advancing ChE inhibitors into the clinic is their …

Background. Very little knowledge exists on the impact of Alzheimer's disease on the CNS
target site pharmacokinetics (PK). Aim. To predict the CNS PK of cognitively healthy young …