Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …

As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early
mammalian development, they acquire high DNA methylation levels. During this transition …

Primordial germ cells (PGCs) are the germline precursors that give rise to oocytes and
sperm, ensuring the continuation of life. While the PGC specification is extensively studied, it …

An in vitro model of human meiosis would accelerate research into this important
reproductive process and development of therapies for infertility. We have developed a …

Epigenetics play major roles in the regulation of cellular identity. This chapter serves to
describe our collective progress in understanding the epigenetic dynamics and regulators …

An in vitro model of human meiosis would accelerate research into this important
reproductive process and development of therapies for infertility. We have developed a …