Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles
A transmembrane (TMEM) protein with an unknown function is a type of membrane-
spanning protein expressed in the plasma membrane or the membranes of intracellular …
spanning protein expressed in the plasma membrane or the membranes of intracellular …
[HTML][HTML] VSI: The Anoctamins: Structure and Function:“Intracellular” anoctamins
K Kunzelmann, J Ousingsawat, R Schreiber - Cell Calcium, 2024 - Elsevier
Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …
great detail with respect to structure and function, but much less is known about the other …
[HTML][HTML] Orai1/STIMs modulators in pulmonary vascular diseases
Abstract Calcium (Ca 2+) is a secondary messenger that regulates various cellular
processes. However, Ca 2+ mishandling could lead to pathological conditions. Orai1 is a Ca …
processes. However, Ca 2+ mishandling could lead to pathological conditions. Orai1 is a Ca …
The ion channels of endomembranes
M Hu, X Feng, Q Liu, S Liu, F Huang… - Physiological …, 2024 - journals.physiology.org
The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …
Ca2+ storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23
D Watanabe, M Nishi, F Liu, Y Bian… - American Journal of …, 2024 - journals.physiology.org
Mitsugumin 23 (MG23) has been identified as a ball-shaped cation channel in the
sarcoplasmic reticulum (SR) but its physiological role remains unclear. This study aimed to …
sarcoplasmic reticulum (SR) but its physiological role remains unclear. This study aimed to …
DriverDetector: an R package providing multiple statistical methods for cancer driver genes detection and tools for downstream analysis
Z Wang, H Gu, P Qin, J Wang - Heliyon, 2024 - cell.com
Identifying driver genes in cancer is a difficult task because of the heterogeneity of cancer as
well as the complex interactions among genes. As sequencing data become more readily …
well as the complex interactions among genes. As sequencing data become more readily …
Disrupted Endoplasmic Reticulum Ca2+ Handling: A Harβinger of β-Cell Failure
JR Dobson, DA Jacobson - Biology, 2024 - mdpi.com
Simple Summary Simple Summary: Diabetes results from insufficient insulin production and
secretion. Insulin accounts for almost half of the protein produced in the pancreatic β-cell …
secretion. Insulin accounts for almost half of the protein produced in the pancreatic β-cell …
Anoctamins in epithelial transport
K Kunzelmann, J Ousingsawat, R Schreiber - Cell Calcium, 2024 - epub.uni-regensburg.de
Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …
great detail with respect to structure and function, but much less is known about the other …
KCNH6 is essential for insulin secretion by regulating intracellular ER Ca2+ store
FR Xiong, J Lu, JJ Zhu, RX Zhao, YC Zhang… - The FASEB …, 2024 - Wiley Online Library
Appropriate Ca2+ concentration in the endoplasmic reticulum (ER), modulating cytosolic
Ca2+ signal, serves significant roles in physiological function of pancreatic β cells. To …
Ca2+ signal, serves significant roles in physiological function of pancreatic β cells. To …