Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks
M Zhang, X Wang, N Yang, X Zhu, Z Lu, Y Cai… - Science China Life …, 2024 - Springer
Genome-wide association studies (GWASs) have identified over 140 colorectal cancer
(CRC)-associated loci; however, target genes at the majority of loci and underlying …
(CRC)-associated loci; however, target genes at the majority of loci and underlying …
Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study
Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It
can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) …
can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) …
Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons
Human induced pluripotent stem cells (iPSCs) can be differentiated into neurons, providing
living human neurons to model brain diseases. However, it is unclear how different types of …
living human neurons to model brain diseases. However, it is unclear how different types of …
Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study
X Li, Z Liang - Journal of Cellular and Molecular Medicine, 2024 - Wiley Online Library
The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains
unclear. This study aimed to investigate the potential genes underlying this mechanism. GM …
unclear. This study aimed to investigate the potential genes underlying this mechanism. GM …
[HTML][HTML] Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the Dorsolateral Prefrontal …
M MacDonald, PAS Fonseca, K Johnson, EM Murray… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Substance Use Disorders (SUDs) manifest as persistent drug-seeking behavior
despite adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder …
despite adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder …
Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder
AS Warden, NA Salem, E Brenner, GT Sutherland… - bioRxiv, 2024 - biorxiv.org
Alcohol use disorder (AUD) is a prevalent neuropsychiatric disorder that is a major global
health concern, affecting millions of people worldwide. Past molecular studies of AUD used …
health concern, affecting millions of people worldwide. Past molecular studies of AUD used …
Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder
N Green, H Gao, X Chu, Q Yuan, P McGuire, D Lai… - bioRxiv, 2024 - biorxiv.org
Alcohol use disorder (AUD) is likely associated with complex transcriptional alterations in
addiction-relevant brain regions. We characterize AUD-associated differences in cell type …
addiction-relevant brain regions. We characterize AUD-associated differences in cell type …
Divergent gene expression in alcohol and opioid use disorders results in consistent alterations in functional networks in the Dorsolateral Prefrontal Cortex
M MacDonald, PAS Fonseca, K Johnson, EM Murray… - bioRxiv, 2024 - biorxiv.org
Substance Use Disorders (SUDs) manifest as persistent drug-seeking behavior despite
adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder (OUD) …
adverse consequences, with Alcohol Use Disorder (AUD) and Opioid Use Disorder (OUD) …
Uncovering Hidden Connections and Functional Modules via pyPARAGON: a Hybrid Approach for Network Contextualization
MK ARICI - 2024 - open.metu.edu.tr
State-of-the-art omics technologies provide molecular insights into various biological
contexts, such as disease states, patients, and drug perturbations. Network inference and …
contexts, such as disease states, patients, and drug perturbations. Network inference and …