Immune checkpoints (ICPs) can promote tumor growth and prevent immunity‐induced
cancer cell apoptosis. Fortunately, targeting ICPs, such as programmed cell death 1 (PD‐1) …

Macrophages play key roles in atherosclerosis progression, and an imbalance in M1/M2
macrophages leads to unstable plaques; therefore, M1/M2 macrophage polarization …

Adenosine (ADO) is a common chemotherapy-associated immune checkpoint that hinders
anti-tumor immunity-mediated efficacy of chemotherapy. Herein, we created a synthetic high …

The treatment of sepsis caused by multidrug-resistant (MDR) Gram-negative bacterial
infections remains challenging. With these pathogens exhibiting resistance to carbapenems …

Peptides or proteins containing small biomolecular aggregates, such as micelles, bicelles,
droplets and nanodiscs, are pivotal in many fields ranging from structural biology to …

Developing natural nano-platforms with high biocompatibility and natural targeting ability
represents great significance for drug delivery. High-density lipoprotein (HDL), a natural lipid …

The prevalence of cardiovascular diseases continues to be a challenge for global health,
necessitating innovative solutions. The potential of high-density lipoprotein (HDL) mimetic …

Inflammation is a complex process that usually refers to the general response of the body to
the harmful stimuli of various pathogens, tissue damage, or exogenous pollutants. Nuclear …

Tumor heterogeneity remains a significant obstacle in cancer therapy due to diverse cells
with varying treatment responses. Cancer stem‐like cells (CSCs) contribute significantly to …

Messenger RNA (mRNA) has gained marvelous attention for managing and preventing
various conditions like cancer, Alzheimer's, infectious diseases, etc. Due to the quick …