Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective
E Sendra, A Fernández-Muñoz, L Zamorano, A Oliver… - Infection, 2024 - Springer
Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the
top emergent species associated with antimicrobial resistance that has become one of the …
top emergent species associated with antimicrobial resistance that has become one of the …
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
C Chain, JP Sheehan, X Xu, S Ghaffari, A Godbole… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections for which the
development of antibiotics is urgently needed. Unlike most enteric bacteria, P. aeruginosa …
development of antibiotics is urgently needed. Unlike most enteric bacteria, P. aeruginosa …
Role of bacterial multidrug efflux pumps during infection
Multidrug efflux pumps are protein complexes located in the cell envelope that enable
bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for …
bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for …
Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients
BH Pedersen, FB Simões, I Pogrebnyakov… - PLoS …, 2024 - journals.plos.org
Metabolism provides the foundation for all cellular functions. During persistent infections, in
adapted pathogenic bacteria metabolism functions radically differently compared with more …
adapted pathogenic bacteria metabolism functions radically differently compared with more …
Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1
Antibiotic resistance could rapidly emerge from acquiring the mobile antibiotic resistance
genes, which are commonly evolved from an intrinsic gene. The emergence of the plasmid …
genes, which are commonly evolved from an intrinsic gene. The emergence of the plasmid …
Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome
S Lindon, S Shah, DR Gifford, C Lood… - Evolution …, 2024 - academic.oup.com
The emergence and spread of antibiotic resistance in bacterial pathogens is a global health
threat. One important unanswered question is how antibiotic resistance influences the ability …
threat. One important unanswered question is how antibiotic resistance influences the ability …
[HTML][HTML] From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa …
G Urra, E Valdés-Muñoz, R Suardiaz… - International Journal of …, 2024 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a significant threat as a nosocomial
pathogen due to its robust resistance mechanisms and virulence factors. This study …
pathogen due to its robust resistance mechanisms and virulence factors. This study …
Evolution of Resistance against Ciprofloxacin, Tobramycin, and Trimethoprim/Sulfamethoxazole in the Environmental Opportunistic Pathogen Stenotrophomonas …
LE Ochoa-Sánchez, JL Martínez, T Gil-Gil - Antibiotics, 2024 - mdpi.com
Stenotrophomonas maltophilia is an opportunistic pathogen that produces respiratory
infections in immunosuppressed and cystic fibrosis patients. The therapeutic options to treat …
infections in immunosuppressed and cystic fibrosis patients. The therapeutic options to treat …
Inhibition of the blaOXA-48 gene expression in Klebsiella pneumoniae by a plasmid carrying CRISPRi-Cas9 system
Y Hajizadeh, F Badmasti, M Oloomi - Gene, 2024 - Elsevier
Antibiotic resistance is an increasing concern that threatens the effectiveness of treating
bacterial infections. The spread of carbapenem resistant Klebsiella pneumoniae poses a …
bacterial infections. The spread of carbapenem resistant Klebsiella pneumoniae poses a …
Adaptive response of Pseudomonas aeruginosa under serial ciprofloxacin exposure
Understanding the evolution of antibiotic resistance is important for combating drug-resistant
bacteria. In this work, we investigated the adaptive response of Pseudomonas aeruginosa to …
bacteria. In this work, we investigated the adaptive response of Pseudomonas aeruginosa to …