Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair
Gastric cancer (GC) is a common malignancy that presents challenges in patient care
worldwide. The mismatch repair (MMR) system is a highly conserved DNA repair …
worldwide. The mismatch repair (MMR) system is a highly conserved DNA repair …
Genetic determinants of micronucleus formation in vivo
DJ Adams, B Barlas, RE McIntyre, I Salguero… - Nature, 2024 - nature.com
Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …
Impairing hydrolase transport machinery prevents human melanoma metastasis
A Nordlinger, J Del Rio, S Parikh, L Thomas… - Communications …, 2024 - nature.com
Metastases are the major cause of cancer-related death, yet, molecular weaknesses that
could be exploited to prevent tumor cells spreading are poorly known. Here, we found that …
could be exploited to prevent tumor cells spreading are poorly known. Here, we found that …
Gastrointestinal Malignancy: Genetic Implications to Clinical Applications
HE Trembath, JJ Yeh, NE Lopez - Gastrointestinal Malignancies, 2024 - Springer
Advances in molecular genetics have revolutionized our understanding of the pathogenesis,
progression, and therapeutic options for treating gastrointestinal (GI) cancers. This chapter …
progression, and therapeutic options for treating gastrointestinal (GI) cancers. This chapter …
Malignant epithelial neoplasms of the large intestine
SV Walsh, K Sheahan, FA Carey - Morson and Dawson's …, 2024 - Wiley Online Library
Adenocarcinomas of the large bowel are among the most common human malignancies.
This chapter discusses the epidemiology and pathogenesis of large‐bowel cancer. It …
This chapter discusses the epidemiology and pathogenesis of large‐bowel cancer. It …