The function of the ELF3 gene and its mechanism in cancers

Y Ju, S Fang, L Liu, H Ma, L Zheng - Life Sciences, 2024 - Elsevier
Abstract E74-like factor 3 (ELF3) is an important member of the E-twenty-six (ETS)
transcription factor family. ELF3 is expressed in various types of cells and regulates a variety …

[HTML][HTML] Molecular aspects of cervical cancer: a pathogenesis update

V Vallejo-Ruiz, L Gutierrez-Xicotencatl… - Frontiers in …, 2024 - frontiersin.org
Cervical cancer (CC) is a significant health problem, especially in low-income countries.
Functional studies on the human papillomavirus have generated essential advances in the …

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

L Yu, V Majerciak, A Lobanov, S Mirza, V Band, H Liu… - Mbio, 2024 - Am Soc Microbiol
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset of
papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral …

[HTML][HTML] APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway

Q Wang, B Wang, W Zhang, T Zhang, Q Liu… - Archives of Biochemistry …, 2024 - Elsevier
Apelin (APLN) is an endogenous ligand of the G protein-coupled receptor APJ (APLNR).
APLN has been implicated in the development of multiple tumours. Herein, we determined …

[HTML][HTML] Advancing cancer theranostics through biomimetics: A comprehensive review

K Anitha, S Chenchula, V Surendran, B Shvetank… - Heliyon, 2024 - cell.com
Nanotheranostics, especially those employing biomimetic approaches, are of substantial
interest for molecular imaging and cancer therapy. The incorporation of diagnostics and …

[HTML][HTML] Structure and transcription of integrated HPV DNA in vulvar carcinomas

A Van Arsdale, L Turker, YC Chang, J Gould… - npj Genomic …, 2024 - nature.com
HPV infections are associated with a fraction of vulvar cancers. Through hybridization
capture and DNA sequencing, HPV DNA was detected in five of thirteen vulvar cancers …

[HTML][HTML] PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial …

X Li, C Ren, A Huang, Y Zhao, L Wang, H Shen… - Journal of Advanced …, 2024 - Elsevier
Introduction Human papillomavirus (HPV) integration can induce gene expression
dysregulation by destroying higher-order chromatin structure in cervical cancer. Objectives …

[HTML][HTML] Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver …

M Shen, S Chen, X Han, Y Hao, J Wang, L Li… - Cancer Immunology …, 2024 - Springer
Hotspot driver mutations presented by human leukocyte antigens might be recognized by
anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity …

[HTML][HTML] HPV DNA Integration at Actionable Cancer-Related Genes Loci in HPV-Associated Carcinomas

X Sastre-Garau, L Estrada-Virrueta, F Radvanyi - Cancers, 2024 - mdpi.com
Simple Summary In many tumor types, the development of personalized treatments has
been allowed by the optimal molecular characterization of tumor cell genome alterations. In …

Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five …

HH Aarstad, SEE Moe, S Lybak, Ø Bruserud… - Cancers, 2024 - mdpi.com
Simple Summary In cancer, including head and neck cancer (HNC), certain key players in
the body's inflammatory process, such as the interleukin (IL)-6 and IL-1 systems, are …