Therapeutic drug monitoring guidelines in oncology: what do we know and how to move forward? Insights from a systematic review
X Li, Z Song, Z Yi, J Qin, D Jiang… - Therapeutic …, 2024 - journals.sagepub.com
Background: Compared with anti-infective drugs, immunosuppressants and other fields, the
application of therapeutic drug monitoring (TDM) in oncology is somewhat limited. Objective …
application of therapeutic drug monitoring (TDM) in oncology is somewhat limited. Objective …
Is ctDNA ready to outpace imaging in monitoring early and advanced breast cancer?
L Foffano, R Vida, A Piacentini, E Molteni… - Expert Review of …, 2024 - Taylor & Francis
Introduction circulating tumor DNA (ctDNA) and radiological imaging are increasingly
recognized as crucial elements in breast cancer management. While radiology remains the …
recognized as crucial elements in breast cancer management. While radiology remains the …
Antiseizure effect of MEK inhibitor in a child with neurofibromatosis type 1—Developmental and epileptic encephalopathy and optic pathway glioma
S Barrière, C Faure‐Conter, P Leblond… - Epileptic …, 2024 - Wiley Online Library
Abstract Background Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic
disorder due to a mutation in NF1 gene, resulting in phenotypically heterogeneous systemic …
disorder due to a mutation in NF1 gene, resulting in phenotypically heterogeneous systemic …
Determination of alectinib and its active metabolite in plasma by pipette-tip solid-phase extraction using porous polydopamine graphene oxide adsorbent coupled with …
P Zhang, W Wang, J Yin, M Wang, Y Han… - … of Chromatography A, 2024 - Elsevier
Alectinib is known as an effective targeted drug, which has excellent therapeutic effect on
non-small cell lung cancer and can significantly prolong the survival of patients. Therapeutic …
non-small cell lung cancer and can significantly prolong the survival of patients. Therapeutic …
A systematic review and meta‐analysis of the impacts of germline pharmacogenomics on severe toxicity and symptom burden in adult patients with cancer
S Lingaratnam, M Shah, J Nicolazzo… - Clinical and …, 2024 - Wiley Online Library
The clinical application of Pharmacogenomics (PGx) has improved patient safety. However,
comprehensive PGx testing has not been widely adopted in clinical practice, and significant …
comprehensive PGx testing has not been widely adopted in clinical practice, and significant …
Population Pharmacokinetics of Trametinib and Impact of Nonadherence on Drug Exposure in Oncology Patients as Part of the Optimizing Oral Targeted Anticancer …
A Ravix, C Bandiera, E Cardoso, A Lata-Pedreira… - Cancers, 2024 - mdpi.com
Simple Summary Poor adherence to trametinib, an oral anticancer drug, may be the
consequence of side effects that severely impact the patient's quality of life. The significant …
consequence of side effects that severely impact the patient's quality of life. The significant …
A Score to Predict the Clinical Usefulness of Therapeutic Drug Monitoring: Application to Oral Molecular Targeted Therapies in Cancer
A Géraud, D Combarel… - Clinical …, 2024 - Wiley Online Library
Therapeutic drug monitoring (TDM) involves measuring and interpreting drug concentrations
in biological fluids to adjust drug dosages. In onco‐hematology, TDM guidelines for oral …
in biological fluids to adjust drug dosages. In onco‐hematology, TDM guidelines for oral …
Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib
A Yin, GDM Veerman, JGC van Hasselt… - CPT …, 2024 - Wiley Online Library
Insight into the development of treatment resistance can support the optimization of
anticancer treatments. This study aims to characterize the tumor dynamics and development …
anticancer treatments. This study aims to characterize the tumor dynamics and development …
Results of the first international quality control programme for oral targeted oncolytics
EL Giraud, LMH Te Brake… - British Journal of …, 2024 - Wiley Online Library
Aims With the rising number of oral targeted oncolytics and growing awareness of the
benefits of therapeutic drug monitoring (TDM) within the field of oncology, it is expected that …
benefits of therapeutic drug monitoring (TDM) within the field of oncology, it is expected that …
A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral …
Objectives Accumulating evidence argues for a more widespread use of therapeutic drug
monitoring (TDM) to support individualized medicine, especially for therapies where toxicity …
monitoring (TDM) to support individualized medicine, especially for therapies where toxicity …