Hypertension is one of the most commonly treated conditions in modern medical practice,
but despite its long history, it was largely ignored until the midpoint of the 20th century. This …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

Resistant hypertension (RH) is defined as systolic blood pressure (SBP) or diastolic blood
pressure (DBP) that remains. 140 mmHg or. 90 mmHg, respectively, despite an appropriate …

Despite its crucial role in the regulation of vital metabolic and neurological functions, the
genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate …

Background Prior evidence demonstrates that pulse pressure (PP), a surrogate marker of
arterial stiffness, is an independent risk factor for mortality and major adverse cardiovascular …

Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD).
Genome-wide association studies (GWAS) conducted predominantly in populations of …

Genome-wide association studies and candidate gene studies have identified several
genetic variants that might play a role in achieving longevity. This study investigates …

The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt,
and high blood pressure (BP), which led to the major genetic-based experimental model of …

BACKGROUND: It remains unclear whether blood pressure (BP) genetic variants could
modify the efficacy of immediate antihypertensive treatment after acute ischemic stroke. We …

Obesity is an established risk factor for hypertension, but the mechanisms are only partially
understood. We examined whether body mass index (BMI)-related DNA methylation …