Importance Platform trials have become increasingly common, and evidence is needed to
determine how this trial design is actually applied in current research practice. Objective To …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Importance Optimal health care delivery, both now and in the future, requires a continuous
loop of knowledge generation, dissemination, and uptake on how best to provide care, not …

Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …

During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus
on COVID-19-specific studies. To describe the conduct of an international randomized trial …

The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases
due to more predictable development pathways and financial incentives. In contrast, drug …

As durable learning research systems, adaptive platform trials represent a transformative
new approach to accelerating clinical evaluation and discovery in critical care. This …

Background: Clinical trials are increasingly using Bayesian methods for their design and
analysis. Inference in Bayesian trials typically uses simulation-based approaches such as …

Abstract Background and Aims Pragmatic studies designed to test interventions in everyday
clinical settings can successfully complement the evidence from registration and explanatory …

Platform trials are generally regarded as an innovative approach to address clinical
valuation of early stage candidates, regardless of modality as the evidence evolves. As a …