Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Neuropathic pain (NP) is a chronic pain disorder arising from somatosensory nervous
system impairment. Extensive evidence supports the notion that the gut microbiota (GM) is …

Background Mental disorders may be involved in neuroinflammatory processes that are
triggered by gut microbiota. How gut microbiota influence microglia-mediated sensitivity to …

Depression is one of the most prevalent mental disorders today. Over the past decade, there
has been considerable attention given to the field of gut microbiota associated with …

Depression stands as a prominent contributor to global disability, entailing an elevated risk
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …

Communication among the brain, gut and microbiota in the gut is known to affect the
susceptibility to stress, but the mechanisms involved are unclear. Here we demonstrated that …

Background Chronic stress is an important risk factor for the development of major
depressive disorder (MDD). Recent studies have shown microbiome dysbiosis as one of the …

Translational bioinformatics and data science play a crucial role in biomarker discovery as it
enables translational research and helps to bridge the gap between the bench research and …

Background The gut-brain axis and gut microbiota have emerged as key players in
emotional disorders. Recent studies suggest that alterations in gut microbiota may impact …

Background Emerging evidence has demonstrated the impact of psychological stress on
intestinal microbiota, however, the precise mechanisms are not fully understood. Enteric …