Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?
JM Witkin, H Shafique, JL Smith - Biochemical Pharmacology, 2024 - Elsevier
Patients with epilepsy require improved medications. Purinergic receptors were identified as
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors
F Wildner, TS Neuhäusel, A Klemz… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose P2X4 receptors (P2X4R) are ligand gated cation
channels that are activated by extracellular ATP released by neurons and glia. The …
channels that are activated by extracellular ATP released by neurons and glia. The …
GPCR-Gs mediates the protective effects of ginsenoside Rb1 against oxygen-glucose deprivation/re-oxygenation-induced astrocyte injury
X Wang, Y Liu, J Li, J Xie, Y Dai, M Tang - Journal of Traditional Chinese …, 2024 - Elsevier
Objectives To investigate whether the protective actions of ginsenoside Rb1 (Rb1) on
astrocytes are mediated through the G s-type G-protein-coupled receptor (GPCR-G s) …
astrocytes are mediated through the G s-type G-protein-coupled receptor (GPCR-G s) …
EXPLORING P2X7 RECEPTOR ANTAGONISM AS A POTENTIAL THERAPEUTIC INTERVENTION IN ALS USING A HUMAN INDUCED PLURIPOTENT STEM CELL …
AE Johns - 2024 - jscholarship.library.jhu.edu
Extracellular adenosine triphosphate (ATP) binds to metabotropic and ionotropic purine
receptors (P2) on the surface of cells, triggering a variety of intracellular signaling cascades …
receptors (P2) on the surface of cells, triggering a variety of intracellular signaling cascades …
The molecular mechanism for the pain caused by Pterois volitans venom
S Mouchbahani Constance - 2024 - escholarship.mcgill.ca
The wealth of biodiversity in the world's library of venoms and their toxins represents an
enormous untapped resource that could contain the scaffolds for novel therapeutic drugs …
enormous untapped resource that could contain the scaffolds for novel therapeutic drugs …
Exploring the role of P2X receptors in age-related macular degeneration
S Youn - 2024 - open.library.ubc.ca
Purinergic signaling via ATP-activated P2X receptors has been studied in age-related
macular degeneration (AMD), where retinal pigment epithelium (RPE) cells release ATP and …
macular degeneration (AMD), where retinal pigment epithelium (RPE) cells release ATP and …