Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

The human brain demonstrates structural and functional asymmetries which have
implications for ageing and mental and neurological disease development. We used a set of …

There is widespread overlap across major psychiatric disorders, and this is the case at
different levels of observations, from genetic variants to brain structures and function and to …

Measuring differences between an individual's age and biological age with biological
information from the brain have the potential to provide biomarkers of clinically relevant …

Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition
characterized by persistent pain in various body parts, is a leading cause of disability …

Background Sex differences exist in the prevalence and clinical manifestation of several
mental disorders, suggesting that sex-specific brain phenotypes may play key roles …

The complex biological mechanisms underlying human brain aging remain incompletely
understood. This study investigated the genetic architecture of three brain age gaps (BAG) …

Background Neuroimaging-based brain-age delta has been shown to be a mediator linking
cardiovascular risk factors to cognitive function. We aimed to assess the mediating role of …

BackgroundTwo established staging models outline the longitudinal progression in bipolar
disorder (BD) based on episode recurrence or inter-episodic functioning. However …

Background The transition from childhood to adolescence is characterized by enhanced
neural plasticity and a consequent susceptibility to both beneficial and adverse aspects of …