The Human Microbiome Project was a research programme that successfully identified
associations between microbial species and healthy or diseased individuals. However, a …

While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

Animal internal state is modulated by nutrient intake, resulting in behavioral responses to
changing food conditions. The neural mechanisms by which internal states are generated …

The somatosensory nervous system surveils external stimuli at barrier tissues, regulating
innate immune cells under infection and inflammation. The roles of sensory neurons in …

Animals are exposed to many microbes in their environment, some of which have been
shown to colonize various tissues including the intestine. The composition of the intestinal …

The molecular mechanisms underlying diversity in animal behavior are not well understood.
A major experimental challenge is determining the contribution of genetic variants that affect …

Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks
of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions …

Highlights•Bacteria can modulate the physiology of multicellular organisms including
animals.•Engineered bacteria program model animal Caenorhabditis elegans' physiology.• …

Links between the gut microbiota and human health have been supported throughout
numerous studies, such as the development of neurological disease disorders. This link is …

The impact of exposure to microbial pathogens on animal reproductive capacity and
germline physiology is not well understood. The nematode Caenorhabditis elegans is a …