The analysis of antigen-specific T-cell responses has become routine in many laboratories.
Functional T-cell assays like enzyme-linked-immuno-spot (ELISPOT), which depend on …

Pancreatic cancer is a highly lethal disease with a 5-year survival rate of around 11–12%.
Surgery, being the treatment of choice, is only possible in 20% of symptomatic patients. The …

The p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses
can be attributed to p53 malfunction. p53 incorporates a structural Zn site that is required for …

Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast
Asia, especially in South China. The pathogenesis of NPC is complex, and genetic …

Runt-related transcription factor (RUNX) proteins are considered to play various roles in
cancer. Here, we evaluated the anticancer activity of Chb-M′, a compound that specifically …

Dysfunctions caused by missense mutations in the tumour suppressor p53 have been
extensively shown to be a leading driver of many cancers. Unfortunately, it is time …

Cancer continues to be a major global public health concern and one of the foremost causes
of death. Delays in the diagnosis and cure may cause an increase in advanced stage …

Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is
frequently mutated in human cancers. Among various cancer types, the very aggressive high …

Background: Bone metastasis (BM) seriously affects the quality of life and reduces the
survival time of patients with non-small-cell lung cancer (NSCLC). The genomic …

Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not
only in loss of its tumor-suppressive function but also acquisition of dominant-negative and …