Understanding exosomes: Part 1—Characterization, quantification and isolation techniques

RJ Miron, Y Zhang - Periodontology 2000, 2024 - Wiley Online Library
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells
with a diameter in the range of 30–150 nm. Their use has gained great momentum recently …

Multiparametric single-vesicle flow cytometry resolves extracellular vesicle heterogeneity and reveals selective regulation of biogenesis and cargo distribution

AK von Lersner, F Fernandes, PMM Ozawa… - ACS …, 2024 - ACS Publications
Mammalian cells release a heterogeneous array of extracellular vesicles (EVs) that
contribute to intercellular communication by means of the cargo that they carry. To resolve …

Targeted exosome-based nanoplatform for new-generation therapeutic strategies

W Yin, H Ma, Y Qu, S Wang, R Zhao, Y Yang… - Biomedical …, 2024 - iopscience.iop.org
Abstract Exosomes, typically 30–150 nm in size, are lipid-bilayered small-membrane
vesicles originating in endosomes. Exosome biogenesis is regulated by the coordination of …

Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

SI van de Wakker, J Bauzá‐Martinez… - Journal of …, 2024 - Wiley Online Library
Cardiac progenitor cell (CPC)‐derived small extracellular vesicles (sEVs) exhibit great
potential to stimulate cardiac repair. However, the multifaceted nature of sEV heterogeneity …

Herb Extracellular Vesicle-Chitosan-PEGylated Graphene Oxide Conjugate Delivers Estrogen Receptor α Targeting siRNA to Breast Cancer Cells

S Saroj, P Us, S Patil, D Paul, S Saha, A Ali… - ACS Applied Bio …, 2024 - ACS Publications
Herb-based extracellular vesicles (EV), inherently replete with bioactive proteins, RNA,
lipids, and other medicinal compounds, are noncytotoxic and uniquely capable of cellular …

Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment

N Ponomareva, S Brezgin, I Karandashov… - Pharmaceutics, 2024 - mdpi.com
Biological nanoparticles (NPs), such as extracellular vesicles (EVs), exosome-mimetic
nanovesicles (EMNVs) and nanoghosts (NGs), are perspective non-viral delivery vehicles …

Janus kinase inhibitors modify the fatty acid profile of extracellular vesicles and modulate the immune response

AMD Zapata, K Álvarez, GV Duque, J Palacio… - Heliyon, 2024 - cell.com
Background Janus kinase inhibitors (jakinibs) are immunomodulators used for treating
malignancies, autoimmune diseases, and immunodeficiencies. However, they induce …

Development of Liposomes Loaded with Chloroaluminum Phthalocyanine for Application of Photodynamic Therapy in Breast Cancer

KAB Nogueira, AVF Reis, YS de Oliveira… - Journal of …, 2024 - Elsevier
Chloraluminium phthalocyanine (ClAlPc) has potential therapeutic effect for the treatment of
cancer; however, the molecule is lipophilic and may present self-aggregation which limits its …

[HTML][HTML] Impact of donor pool size on the variability of platelet lysate-derived extracellular vesicles for regenerative medicine

AM Amengual-Tugores, C Ráez-Meseguer… - Extracellular Vesicles …, 2024 - oaepublish.com
Aim: The objective of the present study was to determine the variability of platelet lysate-
derived extracellular vesicles (pEV), in terms of characteristics and functionality through …

Extracellular Vesicles: The Challenges on the Way and Engineering Perspectives

N Attia, HG Ibrahim, H Abdulla, M Mashal… - Handbook of Stem Cell …, 2024 - Springer
Extracellular vesicles (EVs) are found in every body fluid and are known to be released by
every human cell. So far, EVs have been classified into three subclasses: Exosomes …