Hypertension, neurodegeneration, and cognitive decline

A Pacholko, C Iadecola - Hypertension, 2024 - Am Heart Assoc
Elevated blood pressure is a well-established risk factor for age-related cognitive decline.
Long linked to cognitive impairment on vascular bases, increasing evidence suggests a …

Pathophysiology of cerebral small vessel disease: a journey through recent discoveries

N Dupré, A Drieu, A Joutel - The Journal of clinical …, 2024 - Am Soc Clin Investig
Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related
small vessel pathologies that affect multiple regions. Disease manifestations range from …

Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

A Kapoor, S Dutt, JPM Alitin, IJ Sible, A Marshall… - Neurobiology of …, 2024 - Elsevier
Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as
white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at …

[HTML][HTML] Assessing cerebrovascular reactivity (CVR) in rhesus macaques (Macaca mulatta) using a hypercapnic challenge and pseudo-continuous arterial spin …

BJ Johnson, ME Lipford, RA Barcus, JD Olson… - NeuroImage, 2024 - Elsevier
Cerebrovascular reactivity (CVR) is a measure of cerebral small vessels' ability to respond to
changes in metabolic demand and can be quantified using magnetic resonance imaging …

Assessment of Small Vessel Function Using 7T MRI in Patients With Sporadic Cerebral Small Vessel Disease: The ZOOM@ SVDs Study

H Van Den Brink, S Pham, JC Siero, T Arts… - Neurology, 2024 - AAN Enterprises
Background and Objectives Cerebral small vessel disease (cSVD) is a major cause of stroke
and dementia, but little is known about disease mechanisms at the level of the small vessels …

Cerebrovascular reactivity to hypercapnia in patients with migraine: A dual‐echo arterial spin labeling MRI study

ES Hoogeveen, N Pelzer, E Ghariq… - … : The Journal of …, 2024 - Wiley Online Library
Objective This study aimed to compare cerebrovascular reactivity between patients with
migraine and controls using state‐of‐the‐art magnetic resonance imaging (MRI) techniques …

Assessment of Small Vessel Function Using 7T MRI in Patients With Sporadic Cerebral Small Vessel Disease

H Brink, S Pham, JC Siero, T Arts… - …, 2024 - epub.ub.uni-muenchen.de
Methods Patients and controls participated in a prospective observational cohort study, the
ZOOM@ SVDs study. Small vessel function measures on 7T-MRI included perforating artery …

[HTML][HTML] 基于磁共振成像老年人脑白质损伤与脑血管储备功能的相关性

罗丽红, 宫文儒, 李梅, 邢希子, 张华 - 中国辐射卫生, 2024 - html.rhhz.net
目的探讨脑血管储备(CVR) 功能与老年人脑白质损伤的相关性. 方法选择2018 年5 月—2019
年7 月山东省济南地区年龄≥ 60 岁的老年人315 例, 进行经颅多普勒(TCD) …

[PDF][PDF] Microvascular brain raspberries: A clinicopathological study

H Ek-Olofsson - 2024 - portal.research.lu.se
A raspberry is a microvascular formation of the human brain that can be encountered during
postmortem neuropathological examinations. Our histopathological definition of a raspberry …

Disease mechanisms and markers of progression in cerebral small vessel disease

R Brown - 2024 - repository.cam.ac.uk
Methods I performed a systematic review of WMH growth and used inverse variance-
weighted meta-analysis to determine the expected WMH change over time in high-risk …