The mitochondrial calcium uniporter: Balancing tumourigenic and anti‐tumourigenic responses

DM Colussi, PB Stathopulos - The Journal of Physiology, 2024 - Wiley Online Library
Increased malignancy and poor treatability associated with solid tumour cancers have
commonly been attributed to mitochondrial calcium (Ca2+) dysregulation. The mitochondrial …

[HTML][HTML] E3 ligases and DUBs target ferroptosis: A potential therapeutic strategy for neurodegenerative diseases

L Lu, C Jifu, J Xia, J Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ferroptosis is a form of cell death mediated by iron and lipid peroxidation (LPO). Recent
studies have provided compelling evidence to support the involvement of ferroptosis in the …

[HTML][HTML] USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway

A Li, S Wang, J Nie, S Xiao, X Xie, Y Zhang… - Cell Death & …, 2024 - nature.com
Abstract Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of
various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly …

Escape from X-chromosome inactivation and sex differences in Alzheimer's disease

QH Song, KX Zhao, S Huang, T Chen… - Reviews in the …, 2024 - degruyter.com
Sex differences exist in the onset and progression of Alzheimer's disease. Globally, women
have a higher prevalence, while men with Alzheimer's disease experience earlier mortality …

[HTML][HTML] A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia

I Fijalkowski, J Wang, Q Jin, J Van Laere, V Serafin… - Leukemia, 2024 - nature.com
NOTCH1 is a transmembrane receptor in a highly conserved signaling pathway that controls
cell fate decisions in various organisms and tissues. In contrast, its dysregulation is …

Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules

Y Zhao, J Huang, K Zhao, M Li, S Wang - Journal of Molecular Medicine, 2024 - Springer
Abstract N6 methyladenosine (m6A) is the most prevalent RNA epigenetic modification,
regulated by methyltransferases and demethyltransferases and recognized by methylation …

Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-β receptorII

T Li, J Huang, A Zeng, N Yu, X Long - Burns, 2024 - Elsevier
Background Keloid scars occur as a result of abnormal wound healing caused by trauma or
inflammation of the skin. The progression of keloids is dependent on genetic and …

[HTML][HTML] Demethyleneberberine Alleviates Pulmonary Fibrosis through Disruption of USP11 Deubiquitinating GREM1

C Ge, M Huang, Y Han, C Shou, D Li, Y Zhang - Pharmaceuticals, 2024 - mdpi.com
Background: Idiopathic pulmonary fibrosis (IPF) is a fatal and chronic interstitial lung
disease. Intricate pathogenesis of pulmonary fibrosis and only two approved medications …

[HTML][HTML] USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling

Y Tang, T Wang, L Gu, Y Xu, Z Yang, W Zhu… - International Journal of …, 2024 - Elsevier
Purpose Radiation-induced pneumonitis (RIP) seriously limits the application of radiation
therapy in the treatment of thoracic tumors, and its etiology and pathogenesis remain …

Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Specific Peptidase 11 (USP11) As a Prognostic and Immunological Biomarker

L Cui, L Yang, B Lai, L Luo, H Deng, Z Chen, Z Wang - 2024 - researchsquare.com
Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Speci c Peptidase 11 (USP11) As
a Prognostic and Immunological Bi Page 1 Page 1/24 Integrative and Comprehensive Pan-cancer …