Activation of the purinergic receptor P2X7 (P2X7R) is believed to be deleterious in
autoimmune diseases and it was hypothesized to play a role in the pathogenesis of MS …

Currently, the genetic variants strongly associated with risk for Multiple Sclerosis (MS) are
located in the Major Histocompatibility Complex. This includes DRB1* 15: 01 and DRB1* 15 …

Background & Aims Association studies have greatly refined the important role of the major
histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects …

Host–pathogen coevolution is defined as the reciprocal evolutionary changes in both
species due to genotype× genotype (G× G) interactions at the genetic level determining the …

Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical
presentation and pathophysiology. Here, we investigated the heterogeneity of MS by …

Although allele frequency data for most HLA loci provide strong evidence for balancing
selection at the allele level, the DPB1 locus is a notable exception, with allele frequencies …

Abstract Objectives The pathology of Tardive Dyskinesia (TD) has yet to be fully understood,
but there have been proposed hypotheses for the cause of this condition. Our team …

Discussion In this study, the first of this kind in Greek sarcoidosis patients, we were
interested if sarcoidosis is associated with specific HLA alleles, and, further, if particular HLA …

Omics biomarkers play a pivotal role in personalized medicine by providing molecular-level
insights into the etiology of diseases, guiding precise diagnostics, and facilitating targeted …

Abstract The Major Histocompatibility Complex (MHC) is a central element in the vertebrate
immune system. While MHC genes are a common target of conservation genomic studies, it …