The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Copper dysmetabolism is associated with various neurodegenerative disorders, making
high‐spatiotemporal‐resolution imaging of Cu2+ in the brain essential for understanding the …

Oxidative stress is involved in the development of several pathologies. The different reactive
oxygen species (ROS) produced during oxidative stress are at the origin of redox post …

Huntington's disease (HD) is a progressive neurodegenerative disorder with clinical
presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is …

Human serum albumin (HSA), the most abundant protein in plasma and cerebrospinal fluid,
not only serves as a crucial carrier of various exogenous and endogenous ligands but also …

Copper ion dys‐homeostasis is linked to neurodegenerative diseases involving amyloid
formation. Even if many amyloidogenic proteins can bind copper ions as monomers, little is …

Abnormal copper ion (Cu2+) levels are considered to be one of the pathological factors of
Parkinson's disease (PD), but the internal relationship between Cu2+ and PD progression …

Copper homeostasis is critical to the functioning of the brain, and its breakdown is linked
with many brain diseases. Copper is also known to interact with the negatively charged lipid …

Cuproptosis is a novel form of regulated cell death, which plays an important role in the
physiological and pathological processes of the human body. Despite the increasing …

Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in
biological tissue during the progression of several human disorders, including Alzheimer's …