Gut microbes in central nervous system development and related disorders
Y Gan, Y Chen, H Zhong, Z Liu, J Geng… - Frontiers in …, 2024 - frontiersin.org
The association between gut microbiota and central nervous system (CNS) development
has garnered significant research attention in recent years. Evidence suggests bidirectional …
has garnered significant research attention in recent years. Evidence suggests bidirectional …
Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2‐heterozygous mouse model of …
Rett syndrome is an X‐linked neurodevelopmental disorder caused by mutation of Mecp2
gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett …
gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett …
Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer's disease mouse model
CM Henningfield, N Soni, RW Lee, R Sharma… - Alzheimer's Research & …, 2024 - Springer
Abstract Background In Alzheimer's disease (AD), microglia surround extracellular plaques
and mount a sustained inflammatory response, contributing to the pathogenesis of the …
and mount a sustained inflammatory response, contributing to the pathogenesis of the …
Journey from lab to clinic: Design, preclinical, and clinical development of systemic, targeted dendrimer-N-acetylcysteine (D-NAC) nanomedicines.
W Liyanage, N Kale, S Kannan… - … in Pharmacology (San …, 2024 - europepmc.org
Drug discovery is challenging task with numerous obstacles in translating drug candidates
into clinical products. Dendrimers are highly adaptable nanostructured polymers with …
into clinical products. Dendrimers are highly adaptable nanostructured polymers with …
Defining the role of plaque-associated microglia in Alzheimer's disease pathogenesis and disease outcomes
CM Henningfield - 2024 - search.proquest.com
Genetic data implicate microglia, the immune cells of the brain, in the development of
Alzheimer's disease (AD). Within the AD brain, microglia surround extracellular plaques and …
Alzheimer's disease (AD). Within the AD brain, microglia surround extracellular plaques and …