Osteoarthritis (OA) is the most prevalent disorder of synovial joint affecting multiple joints. In
the past decade, we have witnessed conceptual switch of OA pathogenesis from a 'wear and …

Osteoporosis is a systemic skeletal disease caused by an imbalance between bone
resorption and formation. Current treatments primarily involve systemic medication and …

Hip fractures are associated with significant disability, high cost, and mortality. However, the
exact biological mechanisms underlying susceptibility to hip fractures remain incompletely …

The genes of Wnt/β-catenin pathway may have potential roles in fat accumulation of Non-
traumatic osteonecrosis of the femoral head (ONFH), but the effects of their variants in the …

Osteoporosis, characterized by compromised bone density and microarchitecture,
represents a significant global health challenge, particularly in aging populations. This …

Clinical genetic testing may identify the appropriate diagnosis in a subset of patients with
low bone mass, multiple or unusual fractures, and severe or early-onset osteoporosis, and …

Bone toxicities are common among paediatric patients treated for acute lymphoblastic
leukaemia (ALL) with potentially major negative impact on patients' quality of life. To identify …

Cortical bone is characterized by a dense solid matrix permeated by fluid-filled pores.
Ultrasound scattering has potential for the non-invasive evaluation of changes in bone …

The previous observational studies could not overcome the effects of confounding variables
and reverse causality. We aimed to determine whether there is a causal relationship …

The aim of this study was to identify single-nucleotide polymorphisms (SNPs) in bone
remodeling-related genes associated with disease severity and bone mineral density (BMD) …