Lung alveolar structure and function are maintained by subsets of alveolar type II stem cells
(AT2s), but there is a need for characterization of these subsets and their associated niches …

Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and
have been historically challenging to isolate or maintain in cell culture. Here, we engineer a …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

Mammalian lung is the important organ for ventilation and exchange of air and blood. Fresh
air and venous blood are constantly delivered through the airway and vascular tree to the …

Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an
exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the …

Type 2 alveolar epithelial cells (AEC2s) are stem cells in the adult lung that contribute to
lower airway repair. Agents that promote the selective expansion of these cells might …

Various infections trigger a storm of proinflammatory cytokines in which IL-6 acts as a major
contributor and leads to diffuse alveolar damage in patients. However, the metabolic …

Background The global pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million …

Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …

Fibroblast Growth Factor Receptors Mediate Cellular Senescence in the Cystic Fibrosis Airway
Epithelium Page 1 1 Fibroblast Growth Factor Receptors Mediate Cellular Senescence in 1 the …